S100A4在喉鳞癌中的表达及临床意义  

The Expression of S100A4 in Laryngeal Squamous Cell Carcinoma and Its Clinical Significance

作　　者：杨国强[1] 陈应超[1] 李里香[2] 张少容[3] 

机构地区：[1]湖北省孝感市中心医院耳鼻咽喉头颈外科,432100 [2]南昌大学第二附属医院病理科,南昌市330006 [3]南昌大学第二附属医院耳鼻咽喉头颈外科

出　　处：《中华全科医学》2012年第7期1070-1071,F0003,共3页Chinese Journal of General Practice

摘　　要：目的探讨喉鳞状细胞癌(LSCC)组织中肿瘤转移相关蛋白S100A4的表达及临床意义。方法采用免疫组织化学EliVision二步法检测S100A4蛋白在42例LSCC组织、20例癌旁正常黏膜组织中的表达并分析其与LSCC临床病理特征的关系。结果①S100A4蛋白在42例LSCC组织中的阳性表达率为31.0%,而在20例癌旁正常黏膜组织中未见阳性表达,两者差异有统计学意义(P<0.01)。②淋巴结转移组S100A4蛋白阳性表达率(50.0%)高于无淋巴结转移组(13.6%),在临床分期中Ⅲ+Ⅳ期S100A4蛋白阳性表达率(44.0%)高于Ⅰ+Ⅱ期(11.8%),差异均有统计学意义(P<0.05);S100A4蛋白在LSCC中的表达与年龄、性别、原发部位、组织学分化程度及T分期无关(均P>0.05)。结论 S100A4蛋白在LSCC的发生、发展中可起重要作用,可作为预测LSCC发生及侵袭转移潜能的参考指标之一。Objective To analyze the expression and clinical significance of tumor metastasis-associated protein S100A4 protein in laryngeal squamous cell carcinoma（LSCC） tissue.Methods The expression of S100A4 protein was measured by using EliVision two steps immunohistochemical technology in 42 cases of LSCC,20 cases of adjacent normal laryngeal mucosa,the relationship of S100A4 expression with clinical pathologic factors in LSCC was also analyzed.Results ①There was 31.0%（13 of 42） of cases with positive expression of S100A4 protein in LSCC tissue,while the positive expression of S100A4 protein was not observed in 20 cases of adjacent normal laryngeal mucosa;there was significant statistical difference between the case group and control group for S100A4 protein expression（P0.01）.②Tumors with lymph node metastases（50.0%） had more S100A4 protein expression than those without metastasis（13.6%）,P0.05;as for the S100A4 protein expression between Ⅲ＋Ⅳ stage and Ⅰ＋Ⅱ stage,the difference was significant（44.0%：11.8%）,P0.05;S100A4 protein expression had no relation to the patient＇s age,sex,tumor site,histological grade and T-stage（P0.05,respectively）.Conclusion S100A4 protein may play an important role in the occurrence and development of LSCC,it was suggested that S100A4 can be a useful marker for predicting tumorigenesis,invasion and metastasis potential of LSCC.

关 键 词：喉肿瘤 癌 鳞状细胞 S100A4蛋白 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤]