度洛西汀治疗广泛性焦虑障碍的临床疗效观察  

Observation on the Clinical Efficacy of Duloxetine for Treatment of Generalized Anxiety Disorder

作　　者：毕波[1] 刘力[1] 魏媛[1] 秦晓霞[1] 

机构地区：[1]中国医科大学附属第一医院,辽宁沈阳110001

出　　处：《医学临床研究》2012年第5期879-881,共3页Journal of Clinical Research

摘　　要：[目的]探讨度洛西汀治疗广泛性焦虑障碍的临床疗效和安全性.[方法]使用度洛西汀门诊治疗49 例广泛性焦虑患者,疗程8 周,并用汉密尔顿焦虑量表（HAMA） 、临床疗效总评量表（CGI） 、药物不良反应评定量表（TESS） 分别在治疗前、治疗第2、4、8周进行评分.依据HAMA总分减分率判定疗效.[结果]治疗第2周起,患者的HAMA评分,CGI评分与治疗前相比均有显著下降（P〈0.05）,治疗第8周有效率为88.49%.不良反应最常见的是头晕、头痛、便秘、恶心,但不影响正常治疗.[结论]度洛西汀治疗广泛性焦虑症有效、安全,不良反应轻.[Objective] To explore the clinical efficacy and safety of duloxetine for the treatment of generalized anxiety disorder. [Methods] Totally 49 patients with generalized anxiety disorder were treated with duloxetine for 8 weeks. Hamilton anxiety scale（HAMA）, clinical global impression scale（CGI） and treatment emergent symptom scale（TESS） before treatment and 2, 4 and 8 weeks after treatment were used for the evaluation. According to the reducing score rate of general score of HAMA, the efficacy was assessed. [Results] Compared with before the treat-ment, HAMA scores and CGI scores decreased dramatically from the second week of the treatment（ P〈0.05）. The effective rate at 8 weeks was 88. 49 %. The common adverse effects were dizziness, headache, constipation and nau-sea, dizziness, but had no influence on the normal treatment. [Conclusion] Duloxetine for the treatment of generalized anxiety disorder is effective and safe, and has slight adverse reaction.

关 键 词：焦虑症/药物疗法 抗抑郁药/治疗应用 

分 类 号：R749.72[医药卫生—神经病学与精神病学]