惠州地区女性乳腺癌危险因素1∶1条件Logistic病例对照研究  

A Conditional Logistic 1:1 Matched Case-control Study on the Risk Factors of Female Breast Cancer in Huizhou Region

作　　者：廖瑜玲[1] 翁清江[1] 游文锋[1] 

机构地区：[1]广东省惠州市第一人民医院肿瘤外科,广东惠州516001

出　　处：《肿瘤药学》2012年第3期229-231,共3页Anti-Tumor Pharmacy

摘　　要：目的探讨惠州地区女性乳腺癌的危险因素,为该地区女性乳腺癌的预防提供依据。方法采用病例对照研究的方法,对285例经病理确诊的乳腺癌患者及285例匹配对照病例进行危险因素的条件采用logistic回归分析。结果单因素分析结果显示,婚姻、文化程度、体重指数、高脂饮食、行经年数、一级亲属乳腺癌病史、妊娠及生育次数等是诱发乳腺癌的危险因素。联合多因素条件logistic回归分析结果显示,文化程度高、行经年数时间长、一级亲属乳腺癌病史和高脂饮食为乳腺癌发生的危险因素;已婚和生育次数为乳腺癌发生的保护因素。结论遗传、饮食习惯、婚育和文化程度等相关因素是惠州地区女性乳腺癌发病的重要危险因素。Objective To investigate the risk factors of female breast cancer in Huizhou region and provide evidence for the prevention of female breast cancer. Methods A case-control study was conducted on 285 cases of breast cancer which were histopathologically confirmed and 285 matched controls via conditional logistic regression analysis. Results Univariate conditional logistic regression analysis showed that the risk factors of breast cancer include marital status, degree of education, body mass index （BMI）, high fat diet, menstruation span, breast cancer history of first-degree relatives, and times of pregnancy and giving birth. While results from multivariate conditional logistic regression analysis showed that higher education level, longer menstruation span, breast cancer history of first-degree relatives and high fat diet were significantly associated with the incidence of female breast cancer, but factors such as the status of being married and times of giving birth were positive for the prevention of breast cancer. Conclusions Heredity, dietary habit, the status of being married, times of giving birth and degree of education all played important roles in the incidence of breast cancer in Huizhou region.

关 键 词：乳腺癌 危险因素 病例对照研究 

分 类 号：R737.9[医药卫生—肿瘤]