男性酒依赖患者戒酒初期对汉字线索注意偏向相关研究  

Investigation of attentional bias to word-related cues in male alcohol dependent patients

作　　者：庞良俊[1] 尹良爽[1] 朱春燕[2] 汪咏梅[1] 董文文[3] 戴兢[1] 杨琪[1] 孙刚强[1] 黄豹[1] 

机构地区：[1]230022合肥,安徽省精神卫生防治中心 [2]安徽医科大学 [3]浙江医院老年科

出　　处：《中华行为医学与脑科学杂志》2012年第6期524-526,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（31100812）

摘　　要：目的探讨戒酒初期男性酒依赖患者（alcohol dependence，AD）注意偏向特点及与相关因素。方法选取30例戒酒初期的男性AD患者以及与其人口学资料相匹配的37例健康对照组（Hc）作为研究对象，采用中文情绪词stroop实验进行注意偏向的测试。结果AD组在中性词、负性词、线索词的反应时[分别为（1382．13±323．38）ms，（1365．76±313．03）ms，（1433．20±342．23）ms]，高于HC组[分别为（797．27±216．97）ms，（794．11±209．41）ms，（799．40±215．82）ms]，差异有统计学意义（t=8．827，P〈0．001；t=8．922，P〈0．01；t=9．234，P〈0．01）；AD组对中性词、负性词的错误数[（3．70±2．56）次，（4．23±2．53）次]，高于HC组[（2．11±1．87）次，（1．92±1．82）次]，差异有统计学意义（t=2．939，P=0．005；t=4．355，P〈0．01）；在线索词错误数方面差异无统计学意义；酒相关线索词的注意偏向与首次饮酒年龄存呈负相关（P〈0．05），与持续饮酒时间及抑郁自评量表得分呈正相关（P〈0．05）；成瘾年龄和焦虑自评量表总分进入回归方程。结论戒酒初期男性AD患者对酒相关线索具有显著的注意偏向，这可能与犒赏中枢的异常激活有关。Objective To explore the attentional biases in male alcohol dependent （AD） patients and the correlations between the attentional bias and alcohol-related factors. Methods A total of 30 recently detoxified male individuals with alcoholism were compared with 37 healthy controls （HC） on the Chinese Emotional Stroop Task using negative, neutral, and alcohol-related words. Results The comparison between AD group （ （ 1382.13 ± 323.38 ） ms, （ 1365.76 ± 313.03 ） ms, （ 1433.20 ± 342.23 ） ms, respectively） and HC group（ （797.27±216.97 ） ms, （794.11 ±209.41 ）ms, （799.40±215.82）ms respectively） on the reaction time of neutral,negative and al- cohol-related words were significant（ t = 8. 822, P 〈 0.001 ; t = 8. 922, P 〈 0.00l ; t = 9. 234, P 〈 0. 001 ）. The er- ror number of of the neutral and negative- related words of the patients（ （3.70 ± 2.56 ）time, （4.23 ± 2.53 ）time ） was worse than that of HC group（ （ 2.11 ± 1.87 ） time, （ 1.92 ± 1.82） time） （ t = 2. 939, P = 0. 005 ; t = 4. 355, P 〈 0.01 ）. Error number of the alcohol- related words between two groups were not significant;Its alcohol-related words attentional bias negative correlation to the age of initial alcohol use（P〈0.05 ） ,and positive correlation to continue drinking and score of self-rating depression scale （P 〈 0.05 ）. Age of addiction and the score of self-rating anxiety scale enter the regression equation of alcohol-related words. Conclusion These results demonstrate that alcoholics have attentional bias in alcohol-related words and reward-related brain regions may be associated with craving a- mong male patients with attentional bias.

关 键 词：酒依赖 注意偏向 STROOP任务 

分 类 号：R749.6[医药卫生—神经病学与精神病学]