过氧化物酶体增殖物激活受体γ配体噻唑烷二酮类在脑缺血中的神经保护作用  

Neuroprotective effects of peroxisolm proliferators-activated receptor γ ligand thiazolidinediones in cerebral ischenda

作　　者：刘瑞光[1] 毕桂南[1] 

机构地区：[1]广西医科大学第一附属医院神经内科,南宁530021

出　　处：《国际脑血管病杂志》2012年第5期372-377,共6页International Journal of Cerebrovascular Diseases

基　　金：广西自然科学基金

摘　　要：噻唑烷二酮类物质为过氧化物酶体增殖物激活受体γ（peroxisome proliferator—activated receptor-γ，PPARγ／）的合成配体。PPARγ,／对多种类型组织均有一定的保护作用，研究涉及的领域包括糖及脂类代谢、癌症、动脉粥样硬化等。目前，噻唑烷二酮类物质在中枢神经系统疾病中的作用备受关注，如脑梗死、多发性硬化、阿尔茨海默病等。文章综述了脑缺血后PPARγ配体噻唑烷二酮类对抑制神经胶质细胞增殖、促进血管生成以及对抗神经元凋亡的作用。Thiazolidinediones are a synthetic ligand of peroxisome proliferator-activated receptor γ （PPARγ）. PPARγ has certain protective effects for several types of tissues. The research covers the areas of glucose, lipid metabolism, cancer and atherosclerosis, etc, At present, the roles of thiazolidinediones in central nervous system diseases have received roach attention, such as cerebral infarction, multiple sclerosis, and Alzheimer＇s disease. This article reviews the effects of PPARγ ligand thiazolidinediones on inhibiting the proliferation of glial ceils, promoting angiogenesis, and antagonizing neuronal apoptosis after cerebral ischemia.

关 键 词：过氧化物酶体增生物激活受体-Γ 噻唑烷二酮类 噻二唑类 脑缺血 神经保护药 

分 类 号：R743.3[医药卫生—神经病学与精神病学]