免疫组织化学方法在肺癌病理诊断中的应用  

Application of Immunohistochemical Method in Pathological Diagnosis of Lung Carcinoma

作　　者：郝春荣[1] 吴翠环[1] 吴人亮[1] 车东媛[1] 许浒[1] 

机构地区：[1]同济医科大学基础医学院病理学教研室,武汉430030

出　　处：《同济医科大学学报》2000年第1期46-48,共3页Acta Universitatis Medicinae Tongji

摘　　要：应用免疫组织化学方法，观察低分子细胞角蛋白（ＣＫ－ＬＭＷ）、神经烯醇化酶（ＮＳＥ）、嗜铬粒蛋白（ＣｇＡ）、突触泡蛋白（Ｓｙｎ）和α_１－抗胰蛋白酶（α_１－ＡＴ）在细支气管肺泡癌、肺乳头状腺癌、肺大细胞癌癌组织中的表达。结果发现，三型肺癌均有神经内分泌分化，细支气管肺泡癌和乳头状腺癌具有多种细胞分化成分。结果支持肺癌细胞来源于共同干细胞的假说。同时说明，在肺癌病理诊断上，免疫组织化学方法具有较为实用的价值。The expression of CK-LMW, neuron specific enolase (NSE), chromogranin A (CgA), synaptophsin and α_1-AT was observed in bronchiole-alveolar carcinoma (BAC), pulmonary large cell carcinoma (PLCC) and pulmonary papillary adenocarcinoma (PPA) immunohistochemically. The results showed that three kinds of tumor cells of lung carcinoma all had neuroendocrine differentiation, and BAC and PPA tumor cells had multi-composition of cell differentiation. The results supported the hypothesis that lung carcinoma originates from the common stem cells with multi-potentiality in differentiation. The results also indicated that immunohistochemistry is of practical values in the pathological diagnosis of lung carcmoma.

关 键 词：免疫组织化学 肺肿瘤 病理学 

分 类 号：R734.202[医药卫生—肿瘤]