导向内照射化疗栓塞治疗56例肝癌随访报告  

Intervention treatment of hepatocellular carcinoma with ^(125) I-lipiodol plus chemotherapeutic drugs and self body hairs: a report of 56 cases

作　　者：许成平[1] 王建新[2] 郑仕中 邵亚男 张宝初[4] 张盛泰[1] 汪云祥[1] 周良[1] 

机构地区：[1]南京医科大学第二附属医院介入科,210011 [2]江苏省启东市人民医院 [3]南京医科大学同位素实验室 [4]启东肝癌防治研究所

出　　处：《中华肿瘤杂志》2000年第1期42-44,共3页Chinese Journal of Oncology

基　　金：江苏省社会发展基金! (BS960 3 7)

摘　　要：目的　为提高肝癌治疗效果 ,以超液态碘化油 (LUF)及体毛颗粒 (H)作为载体 ,12 5I及细胞周期非特异性抗癌药 (CCNSA)为弹头 ,制成能经导管灌注的导向抗癌物ILCH ,并随访其疗效。方法　对 5 6例肝癌患者经股动脉插管至肿瘤供血动脉内灌注ILCH。治疗前后分别做CT、B超、DSA、AFP及血尿中12 5I放射性测定。结果　12 5I与L标记率为 6 0 %～ 90 % ,能与H一起在 10 0 μm直径以下的末梢动脉中长期滞留 ,不通过毛细血管进入全身循环 ,并将抗癌药限制在癌区共同发挥接触性内照射和化疗栓塞作用。术后副作用小 ,无排异反应 ,DSA证实发丝样肿瘤血管和肿瘤染色消失 ,肿瘤直径缩小 5 0 %～ 70 %者 ,占 6 4.3% ;肿瘤无变化或缩小 5 0 %以下者 ,占 35 .7%。临床症状、肝功能及AFP均有改善。 6个月、1,2 ,3年生存率分别为 10 0 %、82 .1%、6 3.1%和 5 5 .6 %。结论　ILCH作为一种新的导向抗癌物治疗肝癌 ,简便易行 ,导向性强 ,可显著提高患者生存质量和生存率。Objective To study the therapeutic effects on primary hepatic cancer of intervention treatment with a preparation consisting of 125 I iodinated lipiodol ultrafluid (LUF) plus self body hairs and cell cycle nonspecific chemotherapeutic agents. Methods The treatment was given to 56 patients with primary hepatic cancer. CT, US, DSA, serum AFP determination, and urine radioactivity were carried out before and after treatment.Results The preparation was found to be held up in the end arteries supplying the tumor for a considerable length of time without passing through blood capillaries into the general circulation. It helped keep the chemotherapeutic drugs and internal radiation staying at the tumor site. The side effects of this treatment were tolerable. No rejection reaction was observed. In thirty six of the 56 patients (64.3%), the tumor reduced by 50%～70% in diameter, and in the remaining 20 patients(35.7%) the reduction in tumor diameter was less than 50% or not at all. The clinical manifestations, liver functions and serum AFP level improved in all cases. The survival rate in 6, 12, 24 and 36 months was 100%, 82.1%, 63.1% and 55.6%, respectively.Conclusion The new intervention treatment for primary liver cancer herein described is easy to perform and can significantly improve survival and quality of life.

关 键 词：肝肿瘤 治疗 化学栓塞 碘125 

分 类 号：R735.7[医药卫生—肿瘤]