经导管肝动脉化疗栓塞联合伽玛刀治疗原发性肝癌的临床应用  

Treatment of primary liver carcinoma using transcatheter hepatic arterial chemoembolization in combination with gamma knife

作　　者：孔鹏[1] 王家平[1] 童玉云[1] 虞丹萍[1] 孙寅[1] 

机构地区：[1]昆明医学院第二附属医院放射科,云南昆明650101

出　　处：《实用放射学杂志》2012年第6期921-925,939,共6页Journal of Practical Radiology

基　　金：云南省科技汁划项目（编号：2009ZC111M）;云南省教育厅科学研究基金资助项日（编号：601090200506）.

摘　　要：目的探讨经肝动脉化疗栓塞（TACE）结合立体定阳体部伽玛刀治疗肝癌的临床疗做。方法将原发中晚期肝癌120例随机分为A、B2组。A组（综合组）：60例，采用TACE＋体部伽玛刀治疗，行行TACE术1-3次后，再进行体部伽玛刀放射治疗。单次剂量为3-6Gy；B组（介入组）：60例，采用单纯TACE术，且行TACE术均在2次以上。并观察比较肿瘤治疗后的近期疗效、患者生存期及并发症。结果综合组与介入组1、2年生存率分别为90％、76％和78．6％、40％，2组生存率比较差异有显著性（P〈0．05）．2组并发症无明最差别。结论TACE结合体部伽玛刀治疗原发性肝癌是一种安全、有效的方法。Objective To evaluate the therapeutic efficacy of transcatheter arteral chemoembolization （TACE） combined with ra diotherapy body gamma knife in treatment of hepatocellular carcinoma （HCC）.Methods 120 patients with HCC were randomlydi vided into two groups. 60 of the 120 patients （A group）were treated with TACE for 1-3 times after given radiotherapy body gain ma knife 2-3 weeks. 60 of the 120 patients （B group） were simply treated with beyond two times TACE. The short terl＇n therapeu tic effect, survival rate and complications of the patienls were assessed. Results The surviwd rate was 90% in 1 year and 76%in 2 yeaars in group B, 78.6 % and 40% in group A, respectively. The difference between group A and B was statistical significance （P〈2 0.05）. There was no significant difference of complications in two group s. Conclusion TACE combined with radiotherapy body gamma knife is a safe and effective method for treating hepatocellular carcinoma.

关 键 词：肝脏 肝癌 化疗栓塞 伽玛刀 介入放射学 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]