人工周期-冻融胚胎移植的性激素变化分析  

Analysis of sex hormone profiles in the patients with artificial endometrial preparation in the frozen-thawed embryo transfer cycles

作　　者：陈希曦[1] 黎淑贞[1] 邓爱民[1] 郭江华[1] 梁细妹[1] 陈晓燕[1] 

机构地区：[1]广东省江门市中心医院生殖中心,广东江门529030

出　　处：《生殖医学杂志》2012年第3期222-225,共4页Journal of Reproductive Medicine

摘　　要：目的探讨性激素的测定是否有助于确定人工周期-冻融胚胎移植的最佳时机。方法回顾性分析人工周期-冻融胚胎移植121周期,比较给予不同剂量雌激素时血中雌二醇(E_2)、黄体生成素(LH)、孕酮(P)水平及子宫内膜厚度;并依据P注射日E_2水平分为<1,098 pmol/L、1,098～2,196 pmol/L、>2,196 pmol/L三组,比较各组的妊娠结局。结果口服雌激素剂量6 mg、8 mg、10 mg、≥12 mg血中E_2、LH水平及子宫内膜厚度差异无统计学意义(P>0.05),而P值均低于1.59 nmol/L,6 mg组的P(1.49 nmol/L)显著高于≥12 mg组(0.89 nmol/L)(P=0.027)。P注射日E_2水平不同的3组患者基本情况、血中LH、P值、子宫内膜厚度、妊娠结局比较,差异均无统计学意义(P>0.05)。而E_2<1,098 pmol/L组与1,098～2,196 pmol/L组相比较,口服雌激素剂量大(P=0.002),作用时间长(P=0.023)。结论血清E_2、LH水平的测定对人工周期-冻融胚胎移植的最佳时机确定无肯定的临床意义。Objective： To investigate the role of sex hormone monitoring in the timing of frozen-thawed embryo transfer in the patients with artificial endometrial preparation. Methods： One hundred and twenty-one cycles of frozen-thawed embryo transfer in the patients treated with different dosages of estradiol （6, 8, 10 and 〉12 mg/d, respectively） were analyzed retrospectively. The serum levels of estradiol （E2）, luteinizing hormone （LH） and progesterone （P）, endometrial thickness and pregnancy outcomes were analyzed. Results： There was no significant difference in the serum levels of E2, LH, P or endometrium thickness among different dose groups. There was no significant difference in clinical outcomes, serum levels of sex hormones or endometrium thickness in the patients with different levels of E2 on progesterone initiation day. Conclusion： Serum E2 and LH monitoring can hardly help to identify the timing of frozen-thawed embryo transfer in the patients with artificial endometrial preparation.

关 键 词：胚胎移植 人工周期 妊娠 

分 类 号：R[医药卫生]