LIN28B 在结肠癌中的表达及其临床意义  

Expression of the LIN28B and its clinical significance in colon carcinoma

作　　者：庞明辉[1,2] 王康[2] 伍刚[2] 张伟[2] 董丹丹[3] 帅平[4] 梁耀泽[1] 胡阳[2] 李平[2] 李国新[1] 

机构地区：[1]南方医科大学南方医院普外科,广州510515 [2]四川省人民医院普外科,成都610072 [3]四川省人民医院病理科,成都610072 [4]四川省人民医院体检中心,成都610072

出　　处：《首都医科大学学报》2012年第3期366-370,共5页Journal of Capital Medical University

基　　金：四川省卫生厅2011年科研项目(110167)~~

摘　　要：目的探讨结肠癌组织中LIN28B的表达及其临床意义。方法选择美国Biomax的结肠癌及正常组织组合微阵列芯片及2003年1月至2004年12月南方医科大学南方医院的149例手术切除结肠癌石蜡标本作为研究对象。用免疫组化法检测组织芯片和石蜡切片中LIN28B蛋白表达并评分。采用χ2检验比较不同LIN28B表达水平和结肠癌病理性特点包括组织分级、恶性肿瘤(tumor,node,metastasis,TNM)分期及淋巴/远处转移之间的关系。结果 LIN28B在结肠癌组织中相比于正常结肠组织高表达,其高表达与肿瘤的低分化、TNMⅢ-Ⅳ期、结肠癌局部淋巴结转移及远处转移有关。多因素Logistic回归分析显示TNM分期是LIN28B高表达的独立危险因素。结论 LIN28B表达与结肠癌病理特征密切相关,有望作为判断结肠癌患者预后的指标。Objective To investigate and evaluate the clinical significance of LIN28B expression in colon cancer. Methods Immunohistochemistry was performed to detect the LIN28B expression in colon cancer tissue mieroarrays and surgically resected paraffin- embedded tissues. The expression of LIN28B was scored by 2 pathologists, and was analyzed usingx2 test to explore its influences on the pathologic characteristics of colon carcinoma. Results LIN28B was upregulated in colon cancer tissue compared to normal mueosa, and its overexpression correlated with poor differentiation, higher TNM grade （]]I -IV ）, ~ympb node and distant metastasis of colon carcinoma. Conclusion LIN28B overexpression correlates with aggressive pathologic characteristics of colon carcinoma, and it may serve as a oroznostic factor of colon cancer patients.

关 键 词：结肠癌 LIN28B 免疫组织化学 病理特征 

分 类 号：R735.3[医药卫生—肿瘤]