图片点探测任务法观察加压诱发的实验性疼痛对健康人注意偏向的影响  

The effect of experimental pain on attentional bias in a pictorial dot-probe task

作　　者：罗艳琳[1] 崔敏[1] 杨延辉[2] 窦鑫[1] 于洋[1] 韩松[1] 李俊发[1] 

机构地区：[1]首都医科大学神经生物学系,北京100069 [2]首都医科大学宣武医院放射科

出　　处：《中华物理医学与康复杂志》2012年第6期431-435,共5页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：基金项目：首都医科大学基础临床科研基金项目（12JL41）

摘　　要：目的采用图片点探测任务法观察加压诱发的实验性疼痛对健康人注意偏向的影响。方法健康大学生志愿受试者32例，在受试者左侧上臂肘横纹上1～2cm处捆绑血压计的止血带，加压到26．66kPa并维持这个压力10min来诱发疼痛。在加压（诱发疼痛）或不加压（无痛）情况下进行正性、负性和中性三类情绪图片点探测认知实验。记录受试者进行认知任务的反应时和错误率，同时记录受试者的实时疼痛强度和疼痛不适度。结果采用左上臂26．66kPa持续加压10min诱发受试者出现中重度疼痛强度（4．9±1．6）与疼痛不适度（4．8±1．8）。结果显示，在无加压（F（1,2）=10．37，P=0．002）与加压实验（F（1,2）=8．16，P=0．005）中，男性受试者的反应时[无加压（482±73）ms，加压（466±82）ms]均短于女性受试者[无加压（536±90）ms，加压（519±100）ms]，差异均有统计学意义（P〈0．01）。加压疼痛时错误率为（2．38±1．49）％，明显高于无加压的（1．09±0．82）％，差异有统计学意义（F（1,2）=10．89，P=0．001）；且在加压疼痛实验中，对负性图片加工的错误率为（3．81±1．73）％，显著高于正性图片的（1．66±0．97）％和中性图片（1．68±0．80）％（P〈0．05）。偏向指数结果显示，在加压疼痛与无加压条件下，受试者对正性图片[加压实验（-5．1±4．8）ms和无加压实验（-4．6±4．0）ms]和负性图片[加压实验（-3．43±6．0）ms和无加压实验（-0．79±4．1）ms]均存在轻度注意回避倾向，且加压疼痛与无加压条件比较，偏向指数差异无统计学意义（P〉0．05）。结论加压疼痛影响图片点探测任务的错误率，且对负性图片错误率的影响最为显著。Objective To investigate the effect of moderate pain on attentional bias towards emotional pictures among healthy subjects. Methods Thirty-two healthy college students aged from 17 to 26 （21.8 ± 2.2; 16 males and 16 females） participated in this study. A tourniquet was tied to each subject＇s left upper arm 1 to 2 cm above the cubits horizontal grain. Pain was inflicted by inflating the tourniquet, and the pressure was maintained at 26.66 kPa. While tourniquet was inflated （with pain） or not （no pain） , each subject was asked to finish a pictorial dot-probe task with three kinds of pictures-emotionally positive, negative and neutral. In experiment 1, subjects performed the dot-probe tasks with the contralateral hand while the tourniquet was tied on the left upper arm without in- flation. In experiment 2 the tourniquet was inflated until the subject completed the dot-probe task （for about 10 min）. The reaction times （RTs） and the error rates （ERs） in the recognition task were recorded, and the intensity of the subject＇s pain and discomfort were measured using a verbal rating scale. Results The subjects reported mod- erate to severe pain with the tourniquet inflated. The RT and ER data were analyzed using two-way analysis of variance （ANOVA） which showed a significant difference between the average RTs of the males （482 ± 73 ms without pain and 466 ±82 ms with pain） and those of the females （536 ±90 ms without pain and 519 ± 100 ms with pain）. The average ER was significantly different between the pain （2.38 ± 1.49）% and no pain （1.09 ± 0.82 ）% conditions in both groups. Holm-Sidak multiple comparison testing showed significant differences in both groups＇ average ER between the negative picture （3.81 ± 1.73） % and the positive picture （ 1.66 ± 0.97 ） % , and between the negative and neutral pictures （ 1.68 ± 0.8） % in the pain condition. Mild attentional avoidance was observed with the positive [ pain condition （ - 5. 1 ± 4.8） ms and no pai

关 键 词：疼痛 注意偏向 情绪图片 点探测任务 

分 类 号：B842[哲学宗教—基础心理学]