NY-ESO-1与MAGE-A1在乳腺癌组织中的表达及意义  

Expression and Significance of Antigens NY-ESO-1 and MAGE-A1 in Breast Carcinoma Tissue

作　　者：梁爽[1] 徐殿国[2] 张振翼[3] 赵琰龙[4] 

机构地区：[1]河北工程大学医学院病理教研室,河北邯郸056002 [2]河北工程大学医学院解剖教研室,河北邯郸056002 [3]邯郸市中心医院 [4]河北工程大学医学院临床学院

出　　处：《肿瘤防治研究》2012年第6期698-700,共3页Cancer Research on Prevention and Treatment

基　　金：河北省邯郸市科学技术局资助项目(1028108103-3)

摘　　要：目的探讨NY-ESO-1与MAGE-A1在乳腺癌组织中的表达及意义。方法健康对照者乳腺组织20例,不同病理类型及分级的病例90例,标本进行免疫组织化学SP法染色;采用Tanaka改良定量记分法测阳性率。结果 NY-ESO-1与MAGE-A1在正常乳腺组织中不表达;乳腺癌组织中NY-ESO-1与MAGE-A1阳性表达率分别为37.78%和23.33%;阳性表达与临床病理各参数不具有相关性(P>0.05)。结论NY-ESO-1和MAGE-A1在乳腺癌组织中呈高特异性表达,对乳腺癌的早期诊断有一定的临床意义。Objective To study the expressions of cancer/testis antigens NY-ESO-1 and MAGE-A1 in breast carcinoma tissue.Methods According to pathological grade and pathologic type,90 breast cancer patients were studied,20 cases of normal breast gland as a control group.Immunohistochemical SP method was performed to detect the expression of antigens NY-ESO-1 and MAGE-A1 and the positive rate was measure by Tanaka-improved quantitative scoring method.Results There was no expression in normal breast tissue.The positive expression rate of NY-ESO-1 and MAGE-A1 was 37.78% and 23.33% respectively in breast cancer tissue,and had no obvious relevance to clinical pathological features（P0.05） Conclusion NY-ESO-1 and MAGE-A1 were expressed with high specificity in breast carcinoma tissue,have slightly clinical significance in diagnosis and immunotherapy of breast carcinoma.

关 键 词：肿瘤-睾丸抗原 MAGE-A1 NY-ESO-1 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]