复合α-TCP透磷灰石骨水泥材料的生物相容性研究  

Biocompatibility of α-TCP brushite bone cement material

作　　者：马建敏[1] 杨洪[2] 王凯[2] 刘璨[2] 赵慧娟[2] 

机构地区：[1]新乡市疾病预防控制中心,河南新乡453003 [2]河南师范大学生命科学学院,河南新乡453007

出　　处：《牙体牙髓牙周病学杂志》2012年第6期339-342,318,共5页Chinese Journal of Conservative Dentistry

基　　金：河南省自然科学基金项目(0411031900)

摘　　要：目的:观察复合α-TCP透磷灰石骨水泥的生物相容性,为该复合骨水泥的临床应用提供动物组织学实验依据。方法:在β-TCP+MCPM骨水泥的基础上添加α-TCP,得到一种改进型透磷灰石骨水泥。以传统的透磷灰石骨水泥为对照组,对其进行体外溶血试验、热源试验、急性毒性试验、皮肤过敏试验、肌内植入试验。结果:α-TCP透磷灰石骨水泥的溶血率<5%,无热源性、无毒性、无皮肤过敏,植入肌肉后无明显炎症反应。结论:α-TCP的透磷灰石骨水泥具有良好的生物相容性和安全性,可作为体内骨替换材料。AIM： To investigate the biocompatibility of α-TCP brushite bone cement. METHOD： α-TCP was introduced to β-TCP ＋ MCPM bone cement to obtain α-TCP brushite bone cement. The material was evaluated by hemolysis test, pyrogen test, acute toxicity test, skin allergy test and muscle implant test. The biocompatibility of α-TCP brushite bone cement was compared with traditional brushite bone cement. RESULTS： The hemolysis rate of α-TCP brushite bone cement was below 5 percent. No pyrogenic, no toxic, no skin allergic, and no obvious inflamma- tory reaction were observs. CONCLUSION： The α-TCP brushite bone cement shows excellent biocompatibility and safety, tence can be used in vivo as a bone substitute material.

关 键 词：α-TCP透磷灰石 骨水泥 生物相容性 

分 类 号：R783.1[医药卫生—口腔医学]