快速处理血样方法与传统方法测定血锂浓度比较  

Comparison of lithium measurement between the rapid treatment of blood samples with traditional method

作　　者：王志勤[1] 姜锋[1] 薛伍洋[1] 郭新胜[1] 沈琪琳[1] 

机构地区：[1]新乡医学院第二附属医院检验科,河南新乡453002

出　　处：《中国临床药理学杂志》2012年第6期474-476,共3页The Chinese Journal of Clinical Pharmacology

基　　金：河南省科技攻关基金资助项目(0124170744)

摘　　要：目的用快速处理血样的方式测定血锂离子(Li+)浓度,对比临床上传统血Li+浓度监测的可靠性。方法快速处理的血清、血浆标本之间及与传统处理的血清样本在相同条件下配对检测Li+浓度,同时与处理方式及时间不同的样本进行比较。结果对于Li+药物浓度检测:快速处理血清组与传统处理血清组比较无显著性差异(P>0.05),与快速处理血浆组及快速离心但不分离血浆组比较,结果均有显著性差异(P<0.05);快速处理血浆组与传统处理血浆组比较无显著性差异(P>0.05),与传统处理血清组比较有显著性差异(P<0.05)。结论传统标本处理模式用于Li+药物浓度监测准确可靠;肝素钠抗凝可导致血Li+浓度升高,临床应慎用。Objective To investigate the reliability of lithium（Li＋） concentration measurement by comparing rapid-treatment blood sample and traditional monitoring method.Methods The Li＋ concentrations of serum and plasma by both rapid-treatment sample method and traditional processing sample method were assayed with the same condition,and comparison was also conducted among samples of different processing time and processing methods.Results For the Li＋ concentration measurement： there was no significant difference between rapid-treatment serum group and traditional serum group（P0.05）,but rapid-treatment serum group compared with rapid-treatment plasma group and after centrifugation without separation plasma group,there were significantly difference（P0.05）.Rapid-treatment plasma group was significantly different from traditional serum group（P0.05）,but was not significantly different from traditional plasma group（P0.05）.Conclusion The traditional sample processing for Li＋ monitoring is reliable and effective.Heparin sodium can induce Li＋ concentration increasing,which should draw clinical attention.

关 键 词：Li+ K+ Na+ Cl- 血清 血浆 离子选择电极 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R96[医药卫生—临床医学]