缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究(英文)  

Mechanistic study on hydrogenation of electron-rich substrates with electron-deficient Rh-BINAP catalyst

作　　者：黄碧玉[1,2] 吴海臣[2] 杨镜奎[1] 

机构地区：[1]中国科学院研究生院化学与化学工程学院,北京100049 [2]中国科学院高能物理研究所,北京100049

出　　处：《中国科学院研究生院学报》2012年第4期571-575,共5页Journal of the Graduate School of the Chinese Academy of Sciences

基　　金：Supported by the Project of the National Natural Science Foundation of China(20972159);the President Fund of GUCAS

摘　　要：合成了4种富电性的脱氢α-氨基酸衍生物,将缺电子催化剂Rh-3,5-CF3-(R)-BINAP用于这几种底物的不对称氢化反应中.讨论了底物上取代基及空间位阻对对映选择性的影响.Four electron-rich α-acetamidocinnamic acid derivatives were prepared and used as substrates in the asymmetric hydrogenation catalyzed by electron-deficient Rh-3, 5-CF3-（ R）- BINAP. Influence of the electronic properties of substituted groups in the substrates and their steric hindrance on the enantioselectivity of the product were discussed.

关 键 词：富电性底物 缺电子催化剂 不对称氢化 机理 

分 类 号：O62[理学—有机化学]