生长激素治疗鞍区肿瘤术后垂体功能减低的研究  

Growth hormone treatment for hypopituitarism after sellar tumor operation

作　　者：吴留洋[1] 霍钢[1] 杜安东[1] 张铃铛[1] 冯青林 唐茂源[1] 原周波[1] 

机构地区：[1]重庆医科大学附属第一医院神经外科,400016

出　　处：《中华内分泌外科杂志》2012年第3期166-169,共4页Chinese Journal of Endocrine Surgery

基　　金：基金项目：重庆市科委自然科学基金（CSTC,2008BB5214）

摘　　要：目的探讨生长激素替代治疗在改善鞍区肿瘤术后生长激素缺乏患者的生活质量上的疗效。方法收集2009年6月至2010年12月，在重庆医科大学附属第一医院神经外科行鞍区肿瘤切除术，术后合并垂体功能低下并来神经外科、内分泌科或电话随访的13名患者，每天给予生长激素0．5单位（约0．17mg）替代治疗，使用QoL—GDHA量表在不同时间分别评估患者的生活质量，结果行t检验。结果使用生长激素替代治疗后1、3、6个月患者的QoL—GDHA评分分别为3．91±2．29、3．38±2．43及3．23±2．28，较治疗前8．69±2．66明显降低（P〈0．05），差异有统计学意义。结论生长激素替代治疗能明显改善鞍区肿瘤术后合并垂体功能减低患者的生活质量。Objective To investigate the effect of growth hormone replacement therapy on life quality of patients with growth hormone deficiency after sellar tumor surgery. Methods The data of 13 patients undergoing sellar tumor resection and suffering postoperative hypopituitarism from Jun. 2009 to Dec. 2010. were collected. Each of them was given daily 0. 5 units growth hormone （ about 0. 17 mg） as replacement therapy. The life quality of patients at different time points was evaluated with QoL-GDHA scale. SPSS 17.0 software was used for statistical analysis, Results 1, 3, and 6 months after treatment, QoL-GDHA score of the patients was 3.91 ± 2.29, 3.38 ± 2. 43, and 3.23 ± 2. 28 repectively, significantly lower than before （8.69 ± 2.66）. The difference had statistical significance （P 〈 0. 05）. Conclusion Growth hormone replacement therapy can significantly improve the life quality of patients with hypopituitarism after sellar tumor surgery. [ Key Words]

关 键 词：生长激素 替代治疗 鞍区肿瘤手术 垂体功能减低 生活质量 

分 类 号：R739.41[医药卫生—肿瘤]