局部晚期宫颈癌动脉栓塞化疗的近期疗效观察  

Short term efficacy of arterial chemoembolization in locally advanced cervical cancer

作　　者：梁桂玲[1] 米建锋[1] 梁宁安[1] 

机构地区：[1]钦州市第二人民医院妇产科,广西535000

出　　处：《中国临床新医学》2012年第6期521-523,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的探讨顺铂联合5-氟脲嘧啶方案经子宫动脉置管96 h续贯化疗治疗局部晚期宫颈癌的近期疗效。方法选择肿瘤直径≥4 cm的Ⅰb_2～Ⅲb期宫颈癌患者29例,通过介入方法双侧子宫动脉内灌注顺铂70 mg/m^2,同时栓塞病轻侧子宫动脉,并留管于病重侧子宫动脉主干,5一氟脲嘧啶4 000 mg/m^296 h持续化疗,观察近期疗效及化疗不良反应。结果完全缓解18例,部分缓解8例,总有效率为89.6%;所有患者均有不同程度胃肠道反应,2例患者出现轻度谷丙转氨酶升高(40一80U/L),6例患者出现Ⅰ～Ⅱ°骨髓抑制,1例出现外阴部皮肤红肿脱皮,经对症处理缓解;无一例出现穿刺感染、血肿、下肢血栓形成,未发现肾功能异常患者。结论子宫动脉插管并栓塞+顺铂联合5-氟脲嘧啶方案续贯化疗对局部晚期宫颈癌患者安全有效。Objective To investigate the short term effect of 96 hours＇ sequential chemotherapy of cisplatin and 5 - fluorouracil program by eatherizing via uterine artery for locally advanced cervical cancer. Methods Twentynine patients with cervical cancer at I b2~ Ⅲ b stage （tumor diameter ≥ 4 cm） received bilateral uterine arterial infusion of DDP 70 mg/m2, while the uterine artery of in the side of light of disease was embolized, and the trunk uterine artery in the side of severe disease was preserved, and 96 hours＇ continuous chemotherapy of 5-fluorouracil 4 000 mg/m2 was performed, efficacy and adverse reactions were observed. Results Among 29 patients, complete remission were found in 18 patients, partial remission in 8 patients, the total effective rate was 89.6%. All patients had varying degrees of gastrointestinal reactions,2 patients had mild elevated alanine aminotransferase （40 ~ 80 U/L）, 6 patients I ~ II o bone marrow suppression. Genital skin irritation peeling was found in one patient, which was relieved after symptomatic treatment. No puncture infection, hematoma, lower extremity thrombosis and renal dysfunction were found. Conclusion Uterine artery embolization plus the sequential chemotherapy of cisplatin combined with 5 - fluorouraeil chemotherapy program in the treatment of patients with locally advanced cervical cancer is safe and effective.

关 键 词：子宫动脉插管 宫颈癌 栓塞 化疗 

分 类 号：R737.33[医药卫生—肿瘤]