日本毛连菜降血糖作用的实验研究  

Study on Hypoglycemic by Picris japoncia

作　　者：张志勇[1] 葛睿[1] 刘恩荔[1] 高建平[1] 

机构地区：[1]山西医科大学药学院,太原030001

出　　处：《中国实验方剂学杂志》2012年第12期215-218,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山西医科大学大学生创新项目基金(教师培训项目)

摘　　要：目的:研究日本毛连菜对正常小鼠及糖尿病模型小鼠血糖的影响。方法:尾静脉注射四氧嘧啶50 mg.kg-1,72 h后血糖高于11.1 mmol.L-1为糖尿病模型。小鼠随机分为6组:正常组、模型组、消渴丸组(0.75 g.kg-1.d-1)、日本毛连菜低、中、高剂量组(1.5,3,6 g.kg-1.d-1),ig给予药物14 d,测定空腹血糖,并进行了日本毛连菜急性毒性实验。结果:给药14 d后,日本毛连菜水提物低、中、高剂量组的血糖值分别达到(7.52±1.47),(7.33±2.99),(7.79±1.84)mmol.L-1,与模型组比较有显著性差异(P<0.05)。急性毒性实验表明最大给药量为120 g.kg-1。结论:日本毛连菜对实验性高血糖小鼠有明显降糖作用,且毒性较小。Objective： To investigate the effect of the water extract from Picris japoncia Thunb on blood glucose in normal mice and diabetic model mice. Method： Diabetic model in mice was induced by caudal vein injection of 50 mg·kg^-1 alloxan. Mice were randomly divided into 6 groups： control group, model group, Xiaokewan pill group （0.75 g·kg^-1·d^-1 ） , low dose, moderate dose and high dose groupsof P. japoncia （ 1.5, 3, 6 g·kg^-1·d^-1）. The drugs were administrated to mice for 14 days. Determination of fasting blood glucose by blood sampling, in the corresponding time, and acute toxicity experiment were carried out. Result： The blood glucose value of low dose, moderate dose and high dose group of P. japoncia achieved respectively was （7.52± 1.47）, （7.33 ±2.99）, （7.79 ± 1.84） mmol·L^-1 after administrated for 14 days, there were significant difference in blood glucose value compared with model group. The acute toxicity experiment revealed that the maximum dose of intragastric administration was 120 g·kg^-1. Conclusion： The total extracts of P. japoncia had obvious hypoglycemic activity and little toxicity in hyperglycemia model mice.

关 键 词：日本毛连菜 降血糖 糖尿病模型 

分 类 号：R285.5[医药卫生—中药学]