宫颈高级别病变与HPV感染型别分析  

Analysis of HPV type in high-grade cervical lesions

作　　者：欧亚梦兰[1] 高琨[2] 李力[2] 

机构地区：[1]广西医科大学研究生学院 [2]广西医科大学附属肿瘤医院妇瘤科,南宁530021

出　　处：《中国癌症防治杂志》2012年第2期197-200,共4页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

基　　金：广西教育厅科研基金资助项目(201012MS045)

摘　　要：目的探讨HPV在宫颈高级别病变中的感染率及感染型别。方法采用导流杂交法分别检测CINⅡ～Ⅲ30例和宫颈癌患者160例HPV基因型别,比较HPV感染与宫颈病变的关系。结果 CINⅡ～Ⅲ和宫颈癌患者HPV感染率均为90%,且以单型别感染为主,分别为70.37%(19/27)、81.94%(118/144);在CINⅡ～Ⅲ中HPV58型、52型感染居多,宫颈癌则以HPV16型、18型感染最常见;无论宫颈鳞癌还是宫颈腺癌,以HPV16型检出率最高。结论 HPV16型、18型是宫颈癌的主要致病型,不同病理类型并无HPV型别上的差异;宫颈上皮高级别内瘤变则以HPV58型、52型感染为主;对HPV58型、52型感染者应重视随访。Objective To investigate the infection rate and type of human papillomavirus（HPV ） in high-grade cervical squamous intraepithelial lesions. Methods Types of HPV genes were detected using a gene-chip technique in 30 patients with CIN II -III and 160 patients with cervical cancer.The relationship between HPV infection and cervical lesions was analyzed. Results Rates of HPV infection in both groups were 90% ,with 70.31% （19/27） and 81.94% （118/144） being single-type infections. HPV-58 and HPV-52 were the most frequent types among patients with CIN II-III ,while HPV-16 and HPV-18 were the most frequent types among patients with cervical cancer. HPV-16 was detected most frequently in both squamous cell carcinoma and adenocarcinoma. Conclusion HPV-16 and HPV-18 are the major HPV types associated with cervical cancer,while HPV-58 and HPV-52 are the major types associated with high-grade squamous intraepithelial lesions.

关 键 词：人乳头瘤病毒 宫颈上皮内瘤变 宫颈癌 感染 

分 类 号：R737.33[医药卫生—肿瘤]