缓激肽受体信号转导对心血管疾病的调控机制  

Regulatory Mechanism of Bradykinin Receptor in Signal Transduction and Cardiovascular Diseases

作　　者：刘路路[1,2] 蔡欣[2] 陈京[2] 白波[2] 

机构地区：[1]曲阜师范大学,曲阜273165 [2]济宁医学院,济宁272000

出　　处：《生理科学进展》2012年第3期177-182,共6页Progress in Physiological Sciences

基　　金：国家自然科学基金(30971081;81070961);山东省自然科学基金(ZR2001CM027;ZR2009DZ004);泰山学者建设专项资金资助课题

摘　　要：缓激肽受体是G蛋白偶联受体家族的重要成员之一,它所介导的信号转导对于维持机体内心血管系统动态平衡和炎症方面发挥了重要的作用。近年来,随着荧光共振能量转移(fluorescence resonance energy transfer,FRET)和生物发光共振能量转移(bioluminescence resonance energy trans-fer,BRET)等技术的相继出现,发现缓激肽受体不仅以单体形式存在,还可能以二聚体甚至是高阶寡聚体的形式参与细胞内的病理生理过程。与单体相比,二聚体(或高阶寡聚体)的信号转导和病理功能都产生了相应变化。本文就缓激肽受体及其二聚体所介导的信号途径、生理病理过程及新的研究技术做一简要综述。Bradykinin receptors are an important member of the G protein-coupled receptors family. Bra- dykinin receptor-mediated signal transductions play a significant role in maintaining cardiovascular home- ostasis, regulating pain and inflammation. In recent years, the introduction of fluorescence resonance en- ergy transfer, bioluminescence resonance energy transfer and their extended technologies, confirmed that bradykinin receptors can exist in the formation of dimerizations or even high-order oligomers. Compared with the monomer, its signal transduction and pathological features have changed per, we overview how bradykinin receptor monomeric and dimers regulate physio processes as well as the latest research techniques. accordingly. In this pa- logical and pathological

关 键 词：缓激肽受体 二聚化 信号传导 荧光共振能量转移 生物发光共振能量转移 

分 类 号：R363[医药卫生—病理学]