左氧氟沙星、多西环素联合奥美拉唑治疗幽门螺杆菌感染相关消化性溃疡的临床疗效观察  

Clinical Efficacy of Levfloxacin,Doxycycline and Omeprazole on Helicobacter Pylori Infection-associated Peptic Ulcer

作　　者：贾佳[1] 陈涛[2] 赵逵[1] 

机构地区：[1]遵义医学院附属医院消化内科,563000 [2]湖北医药学院附属人民医院神经内科,442000

出　　处：《中国老年保健医学》2012年第3期49-51,共3页Chinese Journal of Geriatric Care

摘　　要：目的观察左氧氟沙星、多西环素联合奥美拉唑治疗幽门螺杆菌感染相关消化性溃疡的疗效和安全性。方法选择87例Hp阳性消化性溃疡患者,随机分为治疗组与对照组,治疗组给予左氧氟沙星联合多西环素加奥美拉唑,对照组采用克拉霉素联合阿莫西林加奥美拉唑,治疗7天后两组继续用奥美拉唑20mg,2次/天,3周。疗程结束4周后复查胃镜和Hp检查,观察Hp根除率、临床疗效及不良反应。结果治疗组和对照组的有效率分别为91.12%和78.57%,两组比较差异有统计学意义(P<0.05),治疗组和对照组的Hp根除率分别为88.89%和73.81%,差异有统计学意义(P<0.05),两组不良反应均少见。结论左氧氟沙星、多西环素联合奥美拉唑治疗幽门螺杆菌感染相关消化性溃疡疗效显著,Hp根除率高。Objective To observe the effect and safety of triple therapy of omeprazole combined with levofloxacin and doxycyc- line for Helicobacter pylori Infection-associated peptic ulcer. Methods 87 patients with Hp-positive peptic ulcer were random di- vided into treatment group （45 cases） and control group （42 cases）. The treatment group was administered omeprazole with levoflox acin and doxycycline for 7days. The control group was administered omeprazole with clarthromycin and amoxicillin for7 days. Then two groups were treated with omeprazole alone for another 3 weeks~ Four weeks after treatment, the Hp eradicatio n, clinical effects and side effects were observed. Results The effective rate of treatment group and control group were 91.12% and 78.57% , with significant difference （P 〈0.05）. The eradication rate of HP were 88.89% and 73.81% , with significant difference （P 〈0. 05）.The side effects of two groups were seldom. Conclusion The triple therapy of omeprazole combined with levofloxacin and doxycycline have significantly therapy effects in patient with Helicobacter pylori Infection-associated peptic ulcer,with a high eradication rate of Hp.

关 键 词：消化性溃疡 幽门螺杆菌 左氧氟沙星 多西环素 奥美拉唑 

分 类 号：R573.1[医药卫生—消化系统]