p27和cyclinD1在结直肠癌预后方面的价值  

Prognostic implication of p27 and cyclinD1 in colorectal carcinoma

作　　者：李静[1] 尹林林[1] 张钢锋[2] 王静[3] 

机构地区：[1]济南市第四人民医院肿瘤科,济南250031 [2]济南市第四人民医院消化内科,济南250031 [3]济南市第四人民医院病理科,济南250031

出　　处：《山东大学学报（医学版）》2012年第7期105-108,113,共5页Journal of Shandong University:Health Sciences

基　　金：济南市卫生局科研基金[济卫科字(2008)10号]

摘　　要：目的探讨结直肠癌组织中p27、cyclinD1的表达及其在预后方面的价值。方法采用免疫组化的方法检测61例结直肠癌组织中p27、cyclinD1的表达,分析其表达与临床病理学特征和预后的关系及两者之间的相关性。结果结直肠癌组p27和cyclinD1表达分别是72.13%、45.90%,p27的表达与组织分化、淋巴结转移、临床分期呈负相关,p27阴性者5年生存率(38.24%)明显低于p27阳性者(81.64%);而cyclinD1的表达与组织分化、淋巴结转移、临床分期、浸润深度呈正相关,cyclinD1阴性者5年生存率(78.46%)明显高于cyclinD1阳性者(59.63%)。结直肠癌组织中两者表达呈负相关。结论 p27的缺失和cyclinD1的过表达与结直肠癌5年生存率低有关,提示两者可以作为结直肠癌的预后指标之一。Objective To explore the expressions of p27 and cyclinD1 and to assess their prognostic values in the color- ectal carcinoma. Methods The expressions of p27 and cyclinD1 in colorectal carcinoma tissues from 61 patients were examined by immunohistochemistry. The correlations between the expressions of p27 and cyclinD1 and clinicopathologi- cal parameters were evaluated. Results The positive expression rates of p27 and cyclinD1 were 72.13% and 45.90% in the colorectal carcinoma tissues, p27 expression was negatively correlated with the degrees of differentiation, lymph node metastasis and clinical stage. The 5-year survival rate in the p27 negative group （38.24%） was lower compared with the p27 positive group （81.64% ）. The cyclinD1 expression was positively associated with the degrees of differen- tiation, lymph node metastasis, clinical stage and invasion depth. The 5-year survival rates in the cyclinD1 negative group（78.46% ）were higher compared with the cyclinD1 positive group （59.63%）. p27 was negatively correlated with cyclinD1. Conclusion The loss of p27 and over-expression of cyclinD1 are strongly associated with poor 5-year survival rate, which indicates that p27 and cyclinD1 might be taken as prognostic markers for the colorectal carcinoma.

关 键 词：结直肠肿瘤 P27蛋白 CYCLIND1蛋白 免疫组织化学 临床病理学 预后 

分 类 号：R735.3[医药卫生—肿瘤] R730.7[医药卫生—临床医学]