单唾液酸四己糖神经节苷脂钠早期治疗新生儿缺氧缺血性脑病的临床疗效  

Clinical effects of monosialotetrahexosyl ganglioside on neonates with hypoxic-ischemic encephalopathy

作　　者：杨小云[1] 时花[1] 彭万胜[1] 张帆[1] 

机构地区：[1]蚌埠医学院第一附属医院儿科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2012年第6期636-638,共3页Journal of Bengbu Medical College

摘　　要：目的:观察单唾液酸四己糖神经节苷脂钠早期治疗新生儿缺氧缺血性脑病的临床疗效。方法:将62例缺氧缺血性脑病患儿随机分成治疗组32例和对照组30例,对照组采用常规治疗,治疗组在常规治疗基础上于出生后24 h加用单唾液酸四己糖神经节苷脂钠20 mg静脉滴注,每天1次,10～14 d为1疗程。比较2组患儿临床症状体征恢复及新生儿行为神经评分。结果:治疗组临床症状体征的恢复及新生儿行为神经评分均优于对照组(P<0.01)。结论:早期应用单唾液酸四己糖神经节苷脂钠治疗新生儿缺氧缺血性脑病有明显疗效,未见不良反应发生。Objective： To observe clinical effects of monosialotetrahexosyl ganglioside on neonates with hypoxic-ischemic encephalopathy. Methods：Sixty-two neonates with hypoxic-ischemic encephalopathy were randomly divided into the treatment group and the control group. The control group was treated with conventional way; and the treatment group was treated with conventional way combined with monosialotetrahexosyl ganglioside intravenous drip（20 mg per day）for 10- 14 days. The recovery of the clinical symptoms and behavioral neurological assessment scores of all neonates were compared. Results：The clinical symptoms and behavioral neurological assessment scores of the treatment group were better than that of the control group （P 〈 0.01 ）. Conclusions：The early treatment for neonates with hypoxic-ischemic eneephalopatby with monosialotetrahexosyl ganglioside have significant effects and no adverse reactions.

关 键 词：缺氧缺血性脑病 神经节苷脂 新生儿行为神经评分 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R722.1[医药卫生—临床医学]