辛伐他汀联合阿司匹林对伴有颈动脉粥样硬化的脑梗死复发的影响  

Effect of simvastatin combined with aspirin on recurrence of cerebral infarction with carotid atherosclerosis

作　　者：彭艳[1] 邓中云[2] 冯文兵[3] 

机构地区：[1]安徽省滁州市中西医结合医院八病区,239000 [2]安徽省滁州市中西医结合医院B超室,239000 [3]安徽省滁州市中西医结合医院检验科,239000

出　　处：《蚌埠医学院学报》2012年第6期696-698,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨辛伐他汀联合阿司匹林对伴有颈动脉粥样硬化脑梗死复发的影响。方法:将62例伴有颈动脉粥样硬化的脑梗死患者出院后随机分为2组,治疗组32例给予辛伐他汀和阿司匹林口服,对照组30例给予阿司匹林口服,2组均同时服用相关活血化瘀中成药,比较2组患者在2年内脑梗死的复发情况及不良反应发生情况。结果:治疗组和对照组脑梗死复发率分别为6.25%和30.00%,差异有统计学意义(P<0.05)。2组胃肠道和肝脏方面的不良反应差异无统计学意义(P>0.05)。出院2年后,2组脑梗死患者血脂水平、颈动脉斑块面积和颈动脉内膜-中层厚度差异均有统计学意义(P<0.01)。结论:辛伐他汀联合阿司匹林对预防伴有颈动脉粥样硬化的脑梗死复发有确切的临床疗效,且不增加不良反应的发生率。Objective： To study the effect of simvastatin combined with aspirin on recurrence of cerebral infarction with carotid atherosclerosis. Methods：Sixty two cerebral infarction cases associated with carotid atherosclerosis were randomly divided into two groups after discharged, the patients in treatment group were given oral aspirin and simvastatin, and others in control group were given oral aspirin only, at the same time, all cases in both groups were taken blood-activating and stasis-dissolving drugs. The recurrence of cerebral infarction and ineidetlee of adverse reactions within 2 years were analyzed between the two groups. Results： The recurrence rate of cerebral infarction in treatment group （6.25 % ） and in control group （30.00%） was significantly different （P 〈 0.05 ）, and there was no statistical difference about gastrointestinal tract and liver side effects. Two years after discharged, there were statistical differences about blood lipid of levels, area of carotid arterial plaque and intima media thickness between the two groups（P 〈 0.01 ）. Conclusions ： Simvastatin combined with aspirin presents plays the exact clinical effect on prevention recurrence of cerebral infarction with carotid atherosclerosis, and this combination do not increase the incidence of adverse reactions.

关 键 词：脑梗死 颈动脉粥样硬化 辛伐他汀 阿司匹林 

分 类 号：R743.33[医药卫生—神经病学与精神病学]