蚕丝磷酸钙涂层支架的制备和性能  

The preparation and properties of silk fibroin /CaP scaffold

作　　者：张珂[1] 张欣[1] 王淑敏[1] 俞立英[1] 

机构地区：[1]复旦大学附属华山医院口腔科,上海200040

出　　处：《蚌埠医学院学报》2012年第6期727-729,共3页Journal of Bengbu Medical College

摘　　要：目的:通过对蚕丝表面进行磷酸钙涂层,从而增加其成骨效果。方法:将脱胶后的蚕丝放入磷酸钙溶液中,用水热法对蚕丝表面进行矿化,运用扫描电镜、能谱分析仪、X线衍射仪、傅立叶红外对表面改良的蚕丝进行理化性能检测。结果:磷酸钙表面改良处理后磷酸钙均匀涂布于蚕丝表面,矿化蚕丝初始形态并未发生明显改变,表面存在磷酸灰石成分。结论:蚕丝作为一种天然生物纤维,具有良好的生物相容性。经磷酸钙涂层的蚕丝,作为组织工程支架材料具有广阔的发展前景。Objective：To improve bone formation by mineralizing silk fibroin scaffold with calcium phosphate. Methods：Silk fibroin was immerged into calcium phosphate solution, and then mineralized on its surface using hydrothermal method. The characteristics of silk fibroin surface-modified were measured by scanning electron microscopy （SEM）, energy dispersive X-ray microanalysis, X-ray diffraction and Fourier transform infrared spectroscopy. Results：SEM indicated that the surface of silk fibroin was mostly coated by calcium phosphate. The patterns of silk fibroin surface-modified were not changed after immerging in solution, and carbonate apatite distributed on its surface. Conclusions： As a natural material, the silk fibroin possesses good biocompatibility. Silk fibroin/ CaP composite as scaffold material is a promising biomaterial.

关 键 词：蚕丝 支架材料 骨移植 磷酸钙 碳磷灰石 

分 类 号：R783.1[医药卫生—口腔医学]