短暂性脑缺血发作对后继脑梗死神经保护的临床研究  

Clinical study on neuroprotective effect of prior TIA in patients with ischemic cerebral infarction

作　　者：冯慧 宗寿健[2] 王兴臣[3] 

机构地区：[1]山东省茌平县第三人民医院,252100 [2]山东中医药大学 [3]山东中医药大学第二附属医院

出　　处：《山西医药杂志（上半月）》2012年第7期641-642,共2页Shanxi Medical Journal

基　　金：山东省自然科学基金(ZR2009CM124);山东省中医药科学发展计划(2009-119)

摘　　要：目的探讨短暂性脑缺血发作(TIA)对后继脑梗死是否具有神经保护作用。方法根据脑梗死患者梗死前有无TIA史分为脑梗死Ⅰ组(梗死前无TIA)和脑梗死Ⅱ组(梗死前有TIA),分别从TIA持续时间、与脑梗死间隔时间及发作频次与梗死前无TIA患者比较,应用日常生活活动(ADL)评分评定患者预后情况。结果梗死前患者TIA持续时间≤10min、与梗死时间间隔≤7d及发作频次2～3次与梗死前无TIA者相比差异有统计学意义(P<0.05),其Ⅰ级预后较好。结论脑梗死前已发作TIA可能使大脑产生缺血耐受,对后继脑梗死有神经保护作用,且与TIA持续时间、脑梗死间隔时间及发作频次有关。Objective To investigate the neuroprotective effects of TIA on the successive cerebral infarction. Methods According to the history of TIA, patients with cerebral infarction history are divided into cerebral infarction group Ⅰ （preinfarction TIA） and cerebral infarction group Ⅱ （preinfarction）. According to the duration from TIA, cerebral infarction in the interval and attack frequency, ADL scores were used to assess the prognosis of patients compared to the patients without TIA before infaretion. Result Infarction patients before TIA duration 410 min, with infarction time interval 47 days and attack frequency 2 to 3 times compared with no TIA before the infarction was statistically significant （P〈0.05）, patients of grade I have a good prognosis. Conclusion Preattack TIA may cause the brain to produce ischemic tolerance to subsequent cerebral infarction which has a neuroprotective effect, and be related with duration with TIA, cerebral infarction in the interval and attack frequency.

关 键 词：脑缺血发作 短暂性 脑梗死 脑缺血 神经保护 

分 类 号：R743.3[医药卫生—神经病学与精神病学]