复方丹参注射液对急性胰腺炎大鼠血清TNF-α、IL-6、IL-8和PAF水平的影响  

Influence of Compound Salvia Injection on Serum Levels of TNF-α,IL-6,IL-8 and PAF in Rats with Acute Pancreatitis

作　　者：张家墉 贾红英[1] 王少辉[2] 

机构地区：[1]陕西中医学院附属医院,陕西咸阳712083 [2]陕西中医学院,陕西咸阳712046

出　　处：《中西医结合研究》2012年第3期139-142,共4页Research of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察复方丹参注射液对急性胰腺炎(acute pancreatitis,AP)大鼠血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及炎性介质血小板活化因子(PAF)水平的影响,从而探讨其治疗AP的作用机制。方法通过胰胆管逆行注射4%牛磺胆酸钠制作大鼠AP模型,检测复方丹参注射液治疗前后AP大鼠血清TNF-α、IL-6、IL-8、PAF水平的变化。结果复方丹参注射液治疗后AP大鼠血清TNF-α、IL-6、IL-8、PAF明显降低。结论复方丹参注射液通过降低血清TNF-α、IL-6、IL-8和PAF水平,而有效治疗实验性AP。Objective To investigate the influence of compound Salvia injection on serum levels of TNF-a,IL- 6, IL-8 and PAF in rats with acute pancreatitis（AP） ,and then to probe the mechanism of compound Salvia injection in treating acute pancreatitis. Methods The rats received retrograde cholangiopancreatography injection of 4% so- dium taurocholate to establish the rat model of acute pancreatitis. Serum TNF-a, IL-6, IL-8 and PAF levels both be- fore and after the treatment of compound Salvia injection were observed. Results Serum levels of TNF-a, IL-6,IL- 8 and PAF in AP rats significantly reduced after the treatment of compound Salvia injection. Conclusion Com- pound Salvia injection can effectively treat experimental AP through lowering serum levels of TNF-a, IL-6,IL-8 and PAF levels.

关 键 词：复方丹参注射液 胰腺炎 肿瘤坏死因子 白细胞介素-6 白细胞介素-8 血小 板活化因子 

分 类 号：R576[医药卫生—消化系统]