循环热灌注大剂量顺铂治疗胃肠道肿瘤腹水的疗效分析  

Curative effect analysis of circulates the hot irrigation large dose along the platinum treatment gastro-intestinal tract tumor ascites

作　　者：曹汝耀[1] 吕大鹏[2] 李万岱[1] 

机构地区：[1]河北省肃宁县人民医院肿瘤科,河北肃宁062350 [2]北京世纪坛医院肿瘤中心,北京100038

出　　处：《中国医药导报》2012年第19期56-57,共2页China Medical Herald

摘　　要：目的比较循环热灌注大剂量顺铂与单纯灌注化疗治疗胃肠道肿瘤腹水的近期疗效及并发症。方法同期胃肠道肿瘤腹水患者103例,随机分为两组,观察组通过腹腔内穿刺置双管建立循环双通路,先缓慢放出腹腔积液,再行循环热灌注,并于灌注液中加入大剂量顺铂,治疗结束后腹腔内存留1 000～1 500 mL灌注液;对照组置腹腔引流管,先予腹腔放液,后灌注1 000 mL加有大剂量顺铂的液体,24 h后放出液体。两个疗程后对其疗效及副反应进行比较。结果两组103例患者两个疗程后全部可评价疗效,观察组有效率为90.7%,明显高于对照组的51.0%,两组间差异有高度统计学意义(P<0.01),毒副反应均较轻微,两组间差异无统计学意义(P>0.05)。结论循环热灌注大剂量顺铂治疗胃肠道肿瘤腹水安全、微创,不良反应少而轻,近期疗效明显。Objective To compare the efficacy and complications of high-dose cisplatin loop perfusion with simple infusion chemotherapy for the treatment of gastrointestinal tumor ascites. Methods 103 cases of gastrointestinal tumor patients with ascites were divided into two group. Observed group was given high-dose hot cisplatin and the temperature was 45℃. Control group was given high-dose cisplatin without hot temperature, after 24 hours to release liquid. Results Two groups of 105 patients after two courses of all efficacy evaluation, efficient of observation group was 90.7%, significantly higher than the control group （51.0%）. There was a statistically significant difference between two groups （P 〈 0.01）. The side effects were minor and there was no statistically significant difference between two groups （P 〉 0.05）. Conclusion Circulating the hot irrigation with large dose along the platinum treatment gastro-intestinal tract tumor ascites is security. Side effects are few and light and the short-term effect is obvious.

关 键 词：循环热灌注 大剂量顺铂 胃肠道肿瘤 腹水 

分 类 号：R735[医药卫生—肿瘤]