缺血后处理的研究进展  

Progress in Ischemic Postconditioning:A review

作　　者：刘洪端[1] 刘立明[1] 

机构地区：[1]中南大学湘雅二医院胸心外科,长沙410011

出　　处：《中国胸心血管外科临床杂志》2012年第3期309-313,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：缺血后处理是在缺血预处理基础上提出的新概念,因其对器官缺血-再灌注损伤具有良好的保护作用,应用性强,且具有事后性,目前已成为研究保护器官缺血-再灌注损伤方面的热点。但缺血后处理的确切机制及有效诱导时间窗等问题尚不清楚。因此,我们就其发现、发展(远隔后处理、药物后处理)、对心脏、肺、肝、肾和脑等的保护、机制及诱导时间窗等研究新进展进行综述。Ischemia postconditioning is a new concept based on ischemic preconditioning. It has become a hot topic in protection of ischemic-reperfusion injury because of its effective protection, relative ease of application, and postconditioning. However, its precise mechanisms and most effective application methods are still unclear. This review covers recent progress in the understanding, developments （in remote postconditioning and pharmacological postconditioning）, applications to the protection of heart, lung, liver, kidney, and brain, mechanisms and appropriate protocol of ischemic postconditioning.

关 键 词：缺血-再灌注损伤 心肌保护 肺保护 缺血后处理 药物后处理 

分 类 号：R363[医药卫生—病理学]