文拉法辛治疗阿尔茨海默病所致焦虑障碍研究  

Venlafaxine and Paroxetine in the treatment of Alzheimer's disease to anxiety disorder

作　　者：蔡明 罗杨 田雪入 刘志书 

机构地区：[1]四川省江油市精神病医院,四川江油621700

出　　处：《中国民康医学》2012年第13期1556-1558,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较文拉法辛与帕罗西汀治疗阿尔茨海默病所致焦虑障碍的疗效及不良反应。方法:对60例阿尔茨海默病所致焦虑障碍的患者随机分为两组,文拉法辛和帕罗西汀各30例,治疗6周,采用汉密尔顿焦虑量表(HAMA)和不良反应量表(TESS)评定临床疗效和不良反应。结果:经6周治疗后,文拉法辛组和帕罗西汀组有效率分别为86.7%和83.3%,文拉法辛与帕罗西汀疗效接近,但文拉法辛起效更快,不良反应少于帕罗西汀。结论:文拉法辛对于阿尔茨海默病所致焦虑障碍起效更快,不良反应少于帕罗西汀。Objective：To investigate the efficacy and side effect of Venlafaxine in the treatment of Alzheimer disease to anxiety disorder compared to Paroxetine. Methods ：60 cases were divided into two groups randomly, treated with Venlafaxine and Paroxetine respectively for 6 weeks. The Hamilton anxiety scale （HAMA） and treatment emergent symptom scale （TESS） were used to assess the therapelltic effect and side effect respectively. Results： The effective power of Venlafaxine group and Paroxetine group are 86.7% and 83.3% respectively. Findings indicated that efficacy of Venlafaxine was similar to that of Paroxetine, however, Venlafaxine took effect more quickly and its side effects were less than Paroxetine. Conclusions ： Venlafaxine for the treatment of Alzheimerg disease to anxiety disorder took effect more quickly and its side effects were less than Paroxetine.

关 键 词：文拉法辛 帕罗西汀 阿尔茨海默病所致焦虑障碍 

分 类 号：R749.16[医药卫生—神经病学与精神病学]