血管活性肠肽与消化系疾病的研究进展  

Progress in understanding the role of vasoactive intestinal polypeptide in the pathogenesis of digestive diseases

作　　者：吴美玉[1] 胡团敏[1] 

机构地区：[1]中国人民解放军第180医院消化内科,福建省泉州市362000

出　　处：《世界华人消化杂志》2012年第16期1453-1457,共5页World Chinese Journal of Digestology

摘　　要：血管活性肠肽(vasoactive intestinal polypeptide,VIP)既是胃肠激素,又是神经肽,是一种重要的脑肠肽,他涉及生理、生化、细胞生物学、分子生物学、神经学科、免疫学等多种学科.在肝脏、胆道、胰腺、胃肠道等均有分布,与消化系疾病有着密切的关系.在体内病理的循环状态中,VIP降解缓慢,其含量及受体敏感性一旦发生变化,会导致多系统疾病的发生,尤其引起消化系疾病分泌功能的紊乱.本文从VIP生物学特性、功能以及与消化系疾病的关系等方面作一概述.Vasoactive intestinal polypeptide （VIP） is not only a gastrointestinal hormone but also a neuropeptide. It is an important brain-gut peptide that relates to many disciplines such as physiology, biochemistry, cell biology, molecular biology, neurology, and immunology. It is distributed in the liver, biliary tract, pancreas, and gastrointestinal tract, and has close relationship with digestive diseases. In pathological states, VIP was degraded slowly. Once its content and receptor sensitivity change, multiple diseases, especially secretory function disorders of the digestive system, may be caused. This article summarizes the characteristics and functions of VIP as well as its relationship with the pathogenesis of digestive diseases.

关 键 词：血管活性肠肽 生物学特性与功能 消化系疾病 

分 类 号：R57[医药卫生—消化系统]