SLP-2在胃癌中的表达及意义  

Significance of SLP-2 expression in gastric adenocarcinoma

作　　者：张剑[1,2] 李建生[1] 吴敏[2] 赵晔[1] 

机构地区：[1]郑州大学第一附属医院消化内科河南省高等学校临床医学重点学科开放实验室,河南省郑州市450052 [2]郑州大学第五附属医院肿瘤科,河南省郑州市450052

出　　处：《世界华人消化杂志》2012年第19期1778-1781,共4页World Chinese Journal of Digestology

摘　　要：目的:研究SLP-2基因在胃腺癌及正常胃黏膜中的表达情况.方法:应用免疫组织化学法及RT-PCR法分别检测45例及40例胃腺癌及其癌旁正常胃黏膜中SLP-2基因的表达,并结合免疫组织化学结果及胃癌患者的临床病理资料进行分析.结果:免疫组织化学和RT-PCR结果均显示SLP-2在胃腺癌组织中的表达高于正常配对胃黏膜(68.9%vs26.7%,1.12±0.47vs0.63±0.31,均P<0.01),且SLP-2的表达与胃癌TNM分期及有无淋巴结转移相关(2=5.32、4.78,均P<0.05).结论:SLP-2基因在胃腺癌组织中高表达,可能参与胃腺癌的发生发展和转移.AIM： To investigate the expression of stomatin- like protein 2 （SLP-2） in gastric adenocarcinoma and to analyze its significance. METHODS： The expression of SLP-2 mRNA and protein was detected by RT-PCR in 40 cases and by immunohistochemistry in 45 cases of human gastric adenocarcinoma and adjacent tumor-free tissue, respectively. The relationship between SLP-2 expression and clinicopathologic char- acteristics of gastric adenocarcinoma was then analyzed. RESULTS： The expression of SLP-2 mRNA and protein in gastric adenocarcinoma was signifi- cantly higher than that in adjacent tumor-free tissue （68.9% vs 26.7%, 1.12± 0.47 vs 0.63 ± 0.31, both P 〈 0.01）. SLP-2 expression in gastric ad- enocarcinoma was associated with lymph node metastasis and TNM stage （χ^2 = 5.32, 4.78, both P 〈 0.05）, but not with other clinicopathologic characteristics （all P 〉 0.05）. CONCLUSION： The expression of SLP-2 is in- creased in gastric adenocarcinoma. SLP-2 may play important roles in the occurrence, develop- ment and metastasis of gastric adenocarcinoma.

关 键 词：胃腺癌 SLP-2 TNM分期 淋巴结转移 

分 类 号：R735.2[医药卫生—肿瘤]