LASEK与Epi-LASIK术后角膜中央知觉及泪膜稳定性临床研究  

Corneal central consciousness and tear film stability after LASEK and Epi-LASIK

作　　者：宋艳伟[1] 张金莎[1] 格尔勒.陶 

机构地区：[1]新疆医科大学第二附属医院眼科,新疆维吾尔自治区乌鲁木齐市830028

出　　处：《眼科新进展》2012年第6期562-565,共4页Recent Advances in Ophthalmology

摘　　要：目的探讨准分子激光上皮瓣下角膜磨镶术(laser-assisted subepithelial keratomileusis,LASEK)和机械法准分子激光上皮瓣下角膜磨镶术(Epipolis laser in situ keratomileusis,Epi-LASIK)术后不同时间角膜中央知觉和泪膜稳定性恢复的情况。方法将60例(120眼)近视患者随机分为两组各30例(60眼),分别行LASEK和Epi-LASIK,对两组患者术后角膜中央知觉和泪膜稳定性的恢复情况随访24周,并行统计学分析。结果 LASEK组术后2周、4周角膜知觉计测定的角膜中央知觉分别是(44.85±5.78)mm和(49.85±5.01)mm,Epi-LASIK组则为(48.36±6.22)mm和(52.66±5.86)mm,术后2周和4周时LASEK组和Epi-LASIK组角膜中央知觉的结果比较差异均有显著统计学意义(均为P<0.01);术后12周LASEK组和Epi-LASIK组分别为(55.55±4.02)mm和(56.31±4.60)mm,两组比较差异有统计学意义(P<0.05);而术后24周两组分别为(57.31±3.11)mm和(57.62±2.68)mm,差异无统计学意义(P>0.05)。泪膜稳定性表现为术后2周、4周时非侵入性泪膜破裂时间LASEK组分别为(6.88±2.32)s和(9.06±3.15)s,Epi-LASIK组为(7.46±1.56)s和(9.62±1.29)s,两组比较差异均有统计学意义(均为P<0.05);12周、24周LASEK组的值为(11.21±5.13)s和(12.11±1.65)s,Epi-LASIK组分别为(12.06±0.98)s和(12.15±2.10)s,两组比较差异均无统计学意义(均为P>0.05)。结论通过对术后早期泪膜稳定性、角膜中央知觉的恢复比较,Epi-LASIK组患者术后刺激症状相对较轻,能较快恢复视觉。Objective To evaluate the corneal central consciousness and tear film stability at different time after laser-assisted subepithelial keratomileusis （LASEK） and Epipolis laser in situ keratomileus （Epi-LASIK）. Methods Sixty patients （ 120 eyes） with myopia patients were randomly divided into two groups,30 cases （60 eyes） in each group, received LASEK and Epi-LASIK, respectively. The recovery of corneal central consciousness and tear film stability were followed up for 24 weeks after opera- tion,and the statistical analysis was performed. Results The corneal central con- sciousness at postoperative 2 weeks and 4 weeks in LASEK group were （44.85 ± 5.78 ） mm and （49. 85 ± 5.01 ） mm, respectively, which in Epi-LASIK group were （48.35 ± 6. 22） mm and （52.55 ±5.85 ） ram, there were significant differences （ both P 〈 0.01 ）. The corneal central consciousness at postoperative 12 weeks of two groups was （55.55 ±4.02）ram and （56.31 ±4. 50） mm,there was statistical difference（P 〈0.05）, which at postoperative 24 weeks of two groups were （ 57.31 ± 3.11 ） iron and （ 57.62 ± 2.58 ） mm, there was no statistical difference （P 〉 0.05 ）. The tear film stability showed that,the non-invasive break-up time at postoperative 2 weeks and 4 weeks in LASEK group were （ 6. 88 ± 2. 32 ） s and （ 9.06 ± 3. 15 ） s, which in Epi-LASIK group were （7.46 ± 1.55 ） s and （ 9.62 ± 1.29 ） s, there were statistical differences （ both P 〈 0.05 ） ; The non-invasive break-up time at postoperative 12 weeks and 24 weeks in LASEKgroup were （ 11.21 ± 5.13 ） s and （ 12.11 ± 1.65 ） s, which in Epi-LASIK group were （ 12.06 ± 0.98 ） s and （ 12.15± 2.10） s, there was no statistical difference （both P 〉 0.05）. Coneluaion By the comparison of postoperative early corneal central consciousness and tear film stability, the irritative symptoms after Epi-LASIK are less serious, the recovery of corneal con- sciousness is faster.

关 键 词：准分子激光上皮瓣下角膜磨镶术 机械法准分子激光上皮瓣下角膜磨镶术 角膜中央知觉 泪膜稳定性 

分 类 号：R779.6[医药卫生—眼科]