阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质考察  

Evaluation of physicochemical properties for acyclovir/lysine-chitosan nanoparticles in vitro

作　　者：李佳琳[1] 孟萍[1] 刘春年[1] 颜承云[1] 

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《黑龙江医药科学》2012年第3期21-22,共2页Heilongjiang Medicine and Pharmacy

基　　金：黑龙江省自然科学基金项目;编号:D201054

摘　　要：目的:考察阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质。方法:利用激光粒度分析仪,透射电镜,扫描电镜;高效液相色谱仪等测定载药纳米粒的形态、粒径、包封率和载药量,并考察载药纳米粒的体外释放行为。结果:微球呈类圆形,具有明显的核壳;载药的粒子平均粒径大小为107.96nm;包封率为(61.24±0.68)%;载药量为(15.36±0.65)%;体外释放符合Higuchi模型。结论:阿昔洛韦/赖氨酸壳聚糖纳米粒理化性能具有良好的稳定性,符合实验设计要求。Objective：To investigate physical and chemical properties of nanoparticles. Methods：To deter- mine particle size, encapsulation efficiencies, drug loading capacity and release behavior of the drug by laser par- ticle size analyzer, transmission electron microscopy, scanning electron microscopy and high pressure liquid chromatography. Results：The nanoparticles was spherical with obvious nuclear shell, the nanoparticles had av- erage diameter of 107.96nm, encapsulation efficiency of （61.2±0. 68） %, drug loading capacity of （15.36±0. 65）% and the in virto release effect was correspond with Higuchi Equation. Conclusion：The particle stability of acyclovir lysine--chitosan nanoparticles was tranquilization.

关 键 词：阿昔洛韦 赖氨酸壳聚糖 纳米粒 理化性质 

分 类 号：R914[医药卫生—药物化学] TQ46[医药卫生—药学]