莫沙必利对功能性消化不良的疗效及影响因素分析  

Analysis on the efficacy and its influential factors of mosapride for functional dyspepsia

作　　者：明文[1] 张红[1] 贺国斌[1] 向军英[1] 袁聪[1] 左锦[1] 

机构地区：[1]川北医学院附属医院消化内科,四川南充637000

出　　处：《川北医学院学报》2012年第3期243-246,共4页Journal of North Sichuan Medical College

基　　金：四川省教育厅项目(09ZB022)

摘　　要：目的:评价莫沙必利治疗功能性消化不良的影响因素,以提高莫沙必利的疗效。方法:据罗马Ⅲ标准确诊的餐后不适综合征(postprandial distress syndrome,PDS)及餐后不适与上腹痛综合征(epigastric pain syndrome,EPS)重叠的功能性消化不良亚组患者82例,其中餐后不适25例,重叠症状57例,全部予以莫沙必利5 mg×3次/d,治疗4周,所选病例均于治疗前完成Hamilton抑郁量表、SAS焦虑自主评分量表及躯体化症状量表,于治疗前及治疗后第4周完成消化不良症状评分量表。根据治疗前后症状变化情况>50%为治疗有效组。结果:治疗有效人数48例,总的有效率为58.5%,治疗PDS有效率为68.0%(17/25),EPS与PDS重叠的治疗有效率为54.4%(31/57)。治疗有效组伴躯体化症状、抑郁、焦虑、生活经济压力及体重降低明显低于治疗无效组(皆P<0.05)。治疗有效期望值高于无效组(P<0.05)。结论:莫沙必利对功能性消化不良治疗有效,影响莫沙必利疗效的可能因素有抑郁、焦虑、躯体化症状、体重降低、生活经济压力及治疗期望值。Objective：To investigate the effectiveness and its influential factors of mosapride on functional dyspepsia （FD） , and to improve the treatment efficacy of mosapride. Methods： Eighty-two patients with FD including 25 cases with postprandial distress syn- drome （PDS） and 57 cases with overlapping of PDS and epigastric pain syndrome （EPS） based on Rome Ⅲ criteria,all received mosa- pride ,5.0 rag, tid for four weeks. All selected cases completed Hamilton Depression Rating Scale （HAMD） , Zung＇s Self-Rating Anxiety Scale （SAS） ,and somatic symptoms rating scale before treatment, as well as completed dyspepsia symptoms rating scale before and af- ter the four weeks of treatment. According to the changes in the symptoms before and after treatment, patients whose changes where more than 50% were defined as the effective group. Results：After treatment,58.5% （48/82） ,68.0% （ 17/25 ） , and 54.4% （31/57） were effective in patients with total FD, PDS, PDS and EPS, respectively. The effective group, whose symptoms accomplished with somatic symptoms ,depression, anxiety status, stresses of life and economy, and weight loss were remarkably lower than the ineffective group, but the therapy expecting values were higher than the latter （ all P 〈 0.05 ）. Conclusion ： The treatment of mosapride on FD is effective. The possible influential factors of mosapride are depression, anxiety status,weight loss, somatic symptoms, stresses of life and economy, and treatment expectations.

关 键 词：功能性消化不良 莫沙必利 影响因素 

分 类 号：R573.5[医药卫生—消化系统]