椎管内原始神经外胚层肿瘤的诊断与治疗  

Diagnosis and treatment of spinal primitive neuroectodermal tumor

作　　者：顾文韬[1] 车晓明[1] 徐启武[1] 顾士欣[1] 张明广[1] 孙兵[1] 寿佳俊[1] 诸华光[1] 

机构地区：[1]复旦大学附属华山医院神经外科,上海200040

出　　处：《中华神经外科杂志》2012年第6期590-593,共4页Chinese Journal of Neurosurgery

摘　　要：目的 总结椎管内原始神经外胚层肿瘤的临床特点和治疗方法。方法回顾性分析2005年1月至2010年12月上海华山医院治疗8例椎管内原始神经外胚层肿瘤的临床资料，对临床特点、诊断和治疗进行分析、总结。结果8例患者均行显微外科治疗，其中全切除5例，次全切除1例，大部切除1例，部分切除1例。随访1—24个月，其中6例死亡，2例存活，平均生存时间12个月。结论椎管内原始神经外胚层肿瘤发病率低，恶性度高，预后极差，常规病理辅以免疫组化和分子遗传学方法可明确诊断。手术切除肿瘤结合放化疗的综合治疗是目前的主要治疗原则。Objective To summarize the clinical characteristics and treatment of spinal primitive neuroectodermal tumor. Methods Clinical data of 8 patients with spinal cord primitive neuroectodermal tumor were analyzed retrospectively. Results Microsurgery was performed in all of the 8 cases. Total removal was performed in 5 patients, subtotal in 1, most part in 1 and partial in 1. During a follow - up of 1 month to 24 months, Six patients died of disease, and 2 survived, mean follow up of survivor time is 12 months. Conclusions Spinal primitive neuroectodermal tumor is rare, malignant, and poor prognoses tumor. The diagnosis of PNET is by means of routine pathology, immune histology and cytogenetic analysis. Although the best treatment is unavailable due to the limited data, surgery combined with radiotherapy or chemotherapy was recommended.

关 键 词：脊髓肿瘤 显微外科手术 原始神经外胚层肿瘤 尤文肉瘤 

分 类 号：R739.4[医药卫生—肿瘤]