肝病患者血浆内皮素水平的临床观察  

Clinical investigation of plasma levels of endothelin in patients with liver diseases

作　　者：汤正好[1] 李宜[1] 常立非[1] 章秋霞[1] 马良国[1] 

机构地区：[1]安徽省立医院传染科,合肥230001

出　　处：《安徽医科大学学报》2000年第1期48-50,共3页Acta Universitatis Medicinalis Anhui

摘　　要：目的探讨内皮素（ET）在肝病中的血浆水平及其临床意义。方法用特异性放免法测定30例急性肝炎、30例慢性肝炎、周例重症肝炎、对例肝硬化及周例正常人血浆内皮素浓度。结果慢性肝炎、重症肝炎及肝硬化有腹水和无腹水者血浆ET水平分别为73．1ng·L-1±24．7ng·L－1、89．2ng·L－1±25．4ng·L-1、98．5ng·L-1±27．2ng·L－1、78．6ng·L-1±25．1ug·L－1，均明显高于正常人（48ng·L-1±228ng·L-1）（P＜0．01）；慢性肝炎与急性肝炎（58．8ng·L-1±23．7ng·L1-）比较差异有显著性（P＜0．05）；重症肝炎、肝硬化有腹水者与慢性肝炎比较差异亦有显著性（P＜0．01）；肝硬化有腹水者与无腹水者比较差异有显著性（P＜0．01）。结论肝病时血浆ET水平与肝脏损伤的程度有关，血浆ET水平升高可能促进了肝病的发生与发展，并可能与肝硬化患者腹水形成有一定关系。Objective To investigate the plasma levels of endothelin and to assess the clinical significance of en-dothelin in patients with hepatic diseases. Methas Plasma endothelin concentrations were using specific ra-diolmmunoassays in patients with acute hepatitis (n = 30), chronic hepatitis (n = 30), severe hepatltis (n =20), cirrhosis with ascites (n = 15), cirrhOsis withOut ascites (n - 15 ), and normal subjects (n = 20). ResultsThe plasma endOthelin concentrations were significantly higher in patients with chronic hepatitis (73. 1 ng·L1- ± 24. 7 ng· L1- ), severe hepatitis (89 .2 ng· L-1± 25 .4 ng·L-1 ), cirrhosis with ascites (98. 5 ng·L-1 ±27. 2 ng·L -1 ) and cirrhosis without ascites (78.6 ng·L-1 ± 25. 1ng·L- 1 ) than in patients with acute hepatitis(58. 8 ng·L-1± 23. 7 ng·L-1 ) (P < 0. 01 ); patients with severe hepatitis and with cirrhosis had higher plasmalevels of endOthelin as compared with patients with chronic hepatitis (P<0. 01 ). Furthermore, significant dif-ference was observed between cirrhosis with ascites and without ascites (P < 0 .01); no significant differencewas observed between patients with acute hepatitis and normal subjects(48 ng· L- 1± 22. 8 ng·L- 1 ) as well asbetween patients with chronic hepatitis and cirrhotics without ascites (P >0. 05). Conclusion Elevated plasmaendothelin may play a contributory role in development of liver diseases and has a close relation to the fOrmationof ascites in patients with cirrhosis.

关 键 词：肝硬化 肝炎 内皮素 血浆 

分 类 号：R575.202[医药卫生—消化系统] R512.602[医药卫生—内科学]