家兔视网膜缺血-再灌注损伤后ERG的动态变化  

Changes of electroretinography after ischemia and reperfusion injury in rabbit retina

作　　者：杨楠[1] 刘业滋[2] 

机构地区：[1]大连解放军210医院眼科 [2]第一军医大学附属南方医院眼科,510515

出　　处：《眼科新进展》2000年第2期112-113,共2页Recent Advances in Ophthalmology

摘　　要：目的　动态观察家兔视网膜缺血 -再灌注损伤后 ERG的 b波的变化。方法　应用前房灌注加压法使前房内压力高至 16 k Pa,维持 1h,在再灌注后的第 2、7、14天分别记录其ERG,与缺血前 ERG相比较 ,观察 b波的变化幅度。结果　缺血 -再灌注后第 2天 ERG的 b波已经开始下降 ,随时间延长 ,b波振幅呈持续性、进行性下降。结论　视网膜缺血 -再灌注损伤在再灌注后呈持续性、进行性改变。Objective To observe the changes of ERG b wave after ischemia and reperfusion.Methods Retinal ischemia was induced in rabbits by increasing intraocular pressure to 16kPa for 60 minutes and the ERG b wave was examined 2、7、14 days after retinal ischemia and reperfusion respectively.Results The b wave began to fall down from the second day after ischemia and reperfusion,which was (42.3±1.2)%( ±s ) of the pre ischemia value,and then b wave amplicude reduced persistly and progressively.Conclusion Injury followed reperfusion after ischemia in rabbit retina was persist and progressive.

关 键 词：视网膜缺血 再灌注损伤 动物实验 ERG 

分 类 号：R774.102[医药卫生—眼科] R364.12[医药卫生—临床医学]