癌症高发区致癌性多环芳烃的生物监测  

Biomonitoring of carcinogenic polycyclic aromatic hydrocarbons in an area of high incidence of gastrointestinal cancer

作　　者：李欣欣[1,2] 崔师伟[1] 何民富[3] 杨功焕[4] 孙新[1] 

机构地区：[1]中国疾病预防控制中心化学安全与健康重点实验室,中国疾病预防控制中心职业卫生与中毒控制所,北京100050 [2]北京市大兴区疾病预防控制中心 [3]中国疾病预防控制中心慢性非传染性疾病预防控制中心 [4]中国疾病预防控制中心

出　　处：《中国预防医学杂志》2012年第6期423-427,共5页Chinese Preventive Medicine

基　　金：国家高技术研究发展计划(863计划);"十一五"重点项目"环境遗传毒性物质暴露和效应评估关键技术"(2008AA062504)

摘　　要：目的对河南省沈丘县人群多环芳烃(PAHs)暴露水平进行生物监测,评价PAHs暴露与消化道癌症的关联性。方法采用病例对照研究方法,分别募集自河南省沈丘县肿瘤高聚集区和低聚集区的41例食管癌、26例胃癌、17例肝癌患者和19例健康对照,采用固相萃取-超高效液相色谱-串联质谱法检测血中3种致癌性多环芳烃苯并(a)芘(BaP)、苯并(g,h,i)苝[B(g,h,i)P]、二苯并(a,h)蒽[DB(a,h)A]暴露水平和尿中2-羟基萘(2-OHN)、2-羟基芴(2-OHF)、1-羟基芘(1-OHP)3种羟基多环芳烃代谢水平,用SPSS17.0进行数据分析。结果 66.9%的研究对象尿中1-OHP高于一般居民生物暴露限值(0.11μmol/mol Cr)。肿瘤高聚集区和低聚集区人群间多环芳烃暴露水平差异无统计学意义(P>0.05);高、低聚集区病例组血中B(g,h,i)P暴露水平均高于对照组,差异具有统计学意义(P<0.05)。随着体内B(g,h,i)P暴露水平的增加,消化道癌症的发病风险增加。结论该地区研究人群的PAHs暴露水平普遍较高,食管癌、胃癌及肝癌的发病可能与某些致癌性多环芳烃的暴露有关,需要进一步研究进行证实。Objective To measure the exposure levels of polycyclic aromatic hydrocarbons （PAHs） in Shenqiu county of Henan province, and to evaluate the potential correlation between PAHs exposure and gastrointestinal cancer. Methods Based on a case-control study, a total of 84 patients with gastrointestinal cancer and 19 controls were enrolled into the study. Blood and urine samples were collected and the levels of benzo （a） pyrene [B（a）P], benzo （g, h, i） peylene [B（g, h, i）P], dibenzo （a, h） anthracene [DB（a, h） A] in plasma and 2-naphthol （2- OHN）, 2-hydroxyfluorene （20HF） and 1 hydroxyl〉yrene （10HP） in urine were determined by LIPLC-MS/MS with a solid-phase extraction. Results The urinary level of 10HP in 66.9o/oo of all subjects was higher than recom mended BEI. of general population. Except for the plasma level of B （g, h, i） P which was significantly higher in cancer patients compared to that in controls （P〈0.05）, no other big differences of PAHs levels either in plasma or urine were found between subjects from both areas of high and low incidence of gastrointestinal cancer. The study also revealed that the risk of gastrointestinal cancer increased with the higher exposure level of B （g, h, i） P. Conclusions The overall exposure levels of PAHs are relatively higher in this specific area, indicating that these carcinogenic PAHs might be correlated with the occurrance of gastrointestinal cancer. Of course further studies need to be done.

关 键 词：多环芳烃 高聚集区 低聚集区 病例对照 消化道肿瘤 生物监测 

分 类 号：R730.2[医药卫生—肿瘤]