脑室注射左旋硝基精氨酸甲酯对迟发性神经元坏死的影响  

Effect of intraventricular administration L-NAME on delayed neuronal death after recirculation following ischemia

作　　者：张敬军[1] 陈青[2] 江新泉 

机构地区：[1]泰山医学院附属医院,山东泰安271000 [2]泰安卫生学校,山东泰安271000

出　　处：《中国医院药学杂志》2000年第4期200-202,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :探讨一氧化氮合酶抑制剂左旋硝基精氨酸甲酯 (L NAME)在短暂性前脑缺血再灌注损伤中的作用。方法 :钳夹沙土鼠的双侧颈总动脉制造脑缺血模型 ,应用尼氏染色观察迟发性神经元坏死 (DND)的分布与数量。结果 :短暂性前脑缺血再灌注可导致海马CA1区锥体细胞DND ,一氧化氮合酶抑制剂L NAME明显地减少了DND。结论 :LOBJECTIVE:To observe the role of nitric oxide synthase inhibitor(L NAME) during the cerebral ischemia reperfusional injury.METHODS:Bilateral occlusion of common carotid arteries and the morphological changes of the neurons in gerbil hippocampal tissue slices were observed by light microscopy.RESULTS:The results showed that recirculation following ischemia induced delayed neuronal death(DND).L NAME reduced DND.CONCLUSIONS:It is possible that the role of endogenous NOS mediated DND is inhibited by L NAME.

关 键 词：脑缺血 迟发性 神经元坏死 L-NAME 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学]