笑气清醒镇静对肠镜检查的有效性和安全性评价  

Safety and efficacy of nitrous oxide for colonoscopy

作　　者：王寰[1] 陈晓光[1] 黎君[1] 唐红卫[1] 王伟岸[1] 张建国[1] 宋丽[1] 刘海峰[1] 

机构地区：[1]武警总医院消化科,北京100039

出　　处：《武警医学》2012年第6期492-494,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的研究笑气(N2O)清醒镇静在肠镜检查中的安全性和有效性。方法将2011-04至2011-12在我院行笑气清醒镇静肠镜检查的330例患者作为A组,同期常规肠镜检查300例患者作为B组,对其HR、SpO2、反应情况及镇静效果等进行研究分析。结果 A组术中不适反应明显低于B组。A组中,术中HR低于术前[(74.90±13.65)次/min vs(79.16±14.67)次/min,P<0.05],但术中HR在正常安全范围内;术中SpO2高于与术前[99.64±1.04)%vs(99.14±1.35)%,P<0.05]。B组中,术中HR高于术前[(89.80±13.52)vs(79.77±13.35),P<0.05];术中SpO2稍低于与术前[(99.42±1.07)%vs(99.53±1.12)%],但差异无统计学意义。结论笑气清醒镇静肠镜检查提高了肠镜检查的舒适度,安全、可行。Objective To study the safety and effectiveness of nitrous oxide （ ≤70% ） for colonoscopy. Methods A total of 630 patients who underwent colonoseopy from April 2011 to December 2011 were divided into group A （nitrous oxide -colonoscopy group, n = 330） and group B （ conventional eolonoscopy group, n = 300 ）. Their heart rate （ HR）, oxygen saturation and sedative effects were compared. Results The perioperative reaction in group A was obviously lower than in group B. In group A, the perioperative HR was obviously lower than the preoperative HR [ （74.90 ± 13.65）vs （79.16 ± 14.67） ,P 〈0.05] and the perioperative SpO2 was significantly higher than the preoperative SpO2 [ （99.64 ± 1.04） % vs （99.14 ± 1.35 ） % ,P 〈 0.05 ]. In group B, the perioperarive HR was significantly higher than the preoperative HR（89.80 ± 13.52）vs （79.77 ±13.35） ,P 〈0.051 and the perioperative SpO2 was slightly higher than the preoperative SpO2 [ （99.64 ± 1.04） % vs （99.14 ± 1.35 ） %, P 〈 0.05 ], but the difference was not statistically significant. Conclusions Nitrous oxide for colonoscopy is comfortable, safe and feasible.

关 键 词：笑氧混合气(笑气浓度≤70%) 清醒镇静 下消化道 肠镜 评价 

分 类 号：R574[医药卫生—消化系统]