依达拉奉改善一氧化碳中毒迟发性脑病大鼠学习记忆能力和海马CA1区神经元的研究  

Edaravone improves memory and hippocampal CA1 area neurons in rats with delayed neuropsychological sequelae after acute carbon monoxide poisoning

作　　者：汪青松 刘学春 管叶明 刘红娟 王静 黄海丽 王强 

机构地区：[1]解放军第一0五医院神经内科,合肥230031

出　　处：《中国临床保健杂志》2012年第3期277-279,I0004,共4页Chinese Journal of Clinical Healthcare

基　　金：全军十一五医药卫生科研基金课题(06H009);南京军区医药卫生科研基金课题(06MA51)

摘　　要：观察一氧化碳(CO)中毒迟发性脑病大鼠学习记忆能力和海马CA1区神经元的改变,评估自由基清除剂依达拉奉对CO中毒迟发性脑病(DNS)大鼠学习记忆能力和海马CA1区神经元的影响。方法健康雄性40只SD大鼠,进行随机分组,分为对照组、中毒组、0.9%氯化钠注射溶液组、依达拉奉组。采用MORRIS水迷宫测定4组SD大鼠的学习记忆能力,显微镜观察海马CA1区神经元的数量。结果依达拉奉组逃避潜伏期及跨越平台次数优于DNS组及0.9%氯化钠注射溶液组(P<0.05)。依达拉奉组海马CA1区神经元数目明显多于DNS组及0.9%氯化钠注射溶液组(P<0.05)。结论自由基清除剂依达拉奉能改善DNS大鼠受损的空间学习记忆能力,减轻海马CA1区神经元损伤。Objective To observe and evaluate the effect of free radical scavenger edaravone in improving memory and hippocampal CA1 area neurons in rats with delayed neuropsychological sequelae （DNS） after acute carbon monoxide poisoning. Methods 40 male SD rats were randomly divided into 4 groups with 10 rats each group： normal control group, DNS group, saline group and edaravoue group. Spatial learning and memory was detected by Morris water maze in each group. Hippocampal CA1 area neurons were counted by microscope. Results Escape latency and cross platform frequency in edaravone group were better than that in saline group and DNS group （P 〈 0.05）. Hippocampal CA1 area neurons in edaravone group was significantly much more than that in saline group and DNS group （P 〈 0.05 ）. Conclusion Edaravone may improve impaired spatial memory and hippocampal CA1 area neurons in DNS rats.

关 键 词：一氧化碳中毒 谵妄 痴呆 遗忘 认知障碍 依达拉奉 大鼠 sprague-dawley 

分 类 号：R747.9[医药卫生—神经病学与精神病学]