基底细胞样型乳腺癌的临床形态特征及预后分析  

Clinical characteristics and prognosis analysis of the basal-like breast cancer

作　　者：宋振迪[1] 崔伟[1] 李杨[1] 

机构地区：[1]青岛大学医学院附属市立医院普外科,山东青岛266071

出　　处：《中国现代普通外科进展》2012年第6期459-462,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的：观察基底细胞样乳腺癌组织的特异性表达，探讨其临床形态特征，治疗效果如何及预后情况。方法：分析78例乳腺癌患者的临床资料，对其癌组织行病理观察、免疫组化（EnVision法）检测，分析基底细胞样乳腺癌所占的比例，观察患者预后情况。结果：78例患者均为女性，年龄27～78岁，平均49岁。EGFR表达阳性细胞平均比率为48．4％（59／120）。CK5／6旧性细胞平均比率为62．5％（75／120）。基底细胞样乳腺癌的复发率为89％，高于其他类乳腺癌2．6％（2／78）。死亡率在本组78例患者中基底细胞样乳腺癌为2．6％（2／78），非基底细胞样乳腺癌为1．3％。但基底细胞样乳腺癌在本类疾病中的死亡率为9．5％（2／21），明显较高。结论：基底细胞样型乳腺癌在乳腺癌中的发病率较高，其EGFR和CK5／6的高表达率为诊断该疾病提供依据，基底细胞样型乳腺癌患者的放化疗，内分泌治疗等效果不佳，预后差。Objective： To observe the basal-like breast cancer tissue-specific expression, and explore the clinical morphological characteristics, treatment effectiveness and prognosis. Methods： We analyzed 78 cases clinical data of breast cancer patients by immunohistochemistry（EnVision method）, and observed the proportion of cancer tissues and the patients prognosis. Results： 78 patients were all female with the aged by 27 to 78 years, average 49 years old. The average ratio of positive CK5/6 cells was 62.5% （75/120）. The recurrence rate of basal-like breast cancer which was 8.9 percent was higher than that for other types of breast cancer： 2.6% （2/78）. The mortality of basaloid breast cancer in this group of 78 patients was 2.6% （2/78）, while that of non-basal-like breast cancer was 1.3%. The mortality rate of was Basal-like breast cancer in this class of diseases 9.5% （2/21）, significantly higher. Conclusion： The incidence of basal cell-like breast cancer in the breast cancer was higher. The expression of EGFR and CK5/6 was to provide a basis for diagnosing the disease. And the prognosis of basal-like breast cancer patients was poor with radiotherapy and chemotherapy, endocrine therapy.

关 键 词：乳腺癌 基底细胞样 临床特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]