9号染色体臂间倒位遗传效应分析  

Clinical Analysis on Genetic Effect of 26 Cases with Pericentric Inversion of Chromosome 9

作　　者：郑霖[1] 叶长烂[1] 张中芬[1] 江悦华[1] 夏冰[1] 王捷[1] 

机构地区：[1]广州军区广州总医院医学实验科,广东广州510010

出　　处：《中国误诊学杂志》2012年第8期1773-1774,共2页Chinese Journal of Misdiagnostics

摘　　要：目的探讨9号染色体臂间倒位的遗传效应并进行临床意义分析。方法对从2007-01-2011-05因不育不孕和不良孕产史来本室进行染色体检查的1 521例患者,进行染色体核型分析。结果 1 521例患者中检出26例9号染色体臂间倒位,其中不孕不育9例,习惯性流产、自然流产6例,胚胎发育异常、畸形6例。结论 9号染色体臂间倒位可能是导致不孕不育和不良孕产史的原因之一。Objective To investigate the genetic effect and clinical significance of pericentric inversion of chromosome 9.Methods Between January 2007 and May 2011,1521 patients with infertility or adverse pregnancy outcome history were performed karyotype analysis in our laboratory.Results Among those patients,26 cases were found with inversion of chromosome 9,including 9 with infertility,6 with habitual or spontaneous abortion,and 6 with embryo dysplasia or malformation.Conclusions Pericentric inversion of chromosome 9 may be one of the reasons for infertility and adverse pregnancy outcomes.

关 键 词：染色体 人 9对/遗传学 倒位 染色体 

分 类 号：R394[医药卫生—医学遗传学]