TIA患者血清IL-6、IL-18水平与颈动脉内中膜厚度的关系  

Relationships between Carotid Artery lntima-media Thickness and Serum Interleukin-6 and Interleukin-18 on TIA patients

作　　者：朱峻岭[1] 

机构地区：[1]山东省莱芜市人民医院神经内科,271100

出　　处：《中国误诊学杂志》2012年第14期3504-3506,共3页Chinese Journal of Misdiagnostics

摘　　要：目的通过分析颈动脉内中膜厚度（IMT）与血清细胞因子白介素-6（IL-6）、白介素-18（IL-18）水平的关系，探讨IMT增厚的发生机制。方法选择66例短暂性脑缺血发作（TIA）患者（TIA组）作为研究对象，另选择40名健康者作为正常对照组。分别测量其颈动脉IMT值，并分为IMTG1．0mm2亚组和IMT≥1．0mm亚组。利用液相平衡竞争放射免疫分析法（RIA）和酶联免疫吸附法（ELlsA）分别测定了2组的血清IL-6和IL-18水平，并对IMT与IL-6、IL-18的关系进行分析。结果TIA组所有IMT≥1．0mm／1患者血清IL-6、IL-18含量均比正常对照组升高，差异有统计学意义（P〈0．05，PG0．01）；TIA组IMT≥1．0mm亚组患者血清IL-6、IL-18含量比IMT〈1．0mm亚组患者升高，差异有统计学意义（PG0．05）。经Pearson相关分析，TIA组IMT≥1．0n2rn亚组患者IMT与血清IL_18含量呈明显正相关（r=0．551，PGO．01）；TIA组、脑梗塞组IMT≥1．0mm亚组患者IMT与血清IL-6含量无相关性（r=0．303．P=0．058）。结论TIA组IMT增厚的患者血清IL=6、IL-18的水平是升高的。IMT的增厚与血清IL-18含量呈明显正相关，与血清IL-6含量无相关性。IL-6、IL-18可能参与了As的形成过程。Objective To investigate the mechanisms of carotid artery intima-media thickness （IMT} and the relation- ships between carotid artery IMT and the serum levels of interleukin 6, interleukin 18. Methods Carotid artery IMT values were prospectively measured by color Doppler ultrasound in sixty--six cases of transient ischemia attack （TIA） patients who as the study group, and fort}, heathy volunteers as control group. The study groups were divided into two subgroups according to IMT larger or lower than 1.0 mm. Serum IL-6, IL-18 levels were determined in all patients and volunteers with radioimmunoassay{ RIA）and enzyme-linked immunosorbent assay { ELISA） respec- tively. Results There were significant differences in IL-6 and IL-18 levels between IMT^I. 0 mm subgroups and control group （P^0.05, P%0.01）. The IL-6 and IL-18 levels between IMT^I. 0 mm and IMT%I. 0 mm sub- groups had significant differences （P〈0.05）. The levels of serum IL-18 were positively correlated with IMT values in IMT≥1. 0 mm subgroups（Pearson correlation coefficients r= 0.551, P%0.01）, and the levels of serum IL 6 had no correlation with IMT values in IMT≥1. 0 mm subgroups（Pearson correlation coefficients r=0.303, P= 0. 058）. Conclusion The levels of serum IL-6, IL-18 are increased in TIA patients with IMT thickness increased. Serum IL- 18 level is positively correlated with carotid artery IMT,and no correlation between serum IL-6 level and IMT. IL-6 and IL-18 may involve in the development of AS.

关 键 词：脑缺血发作 短暂性/血液 白细胞介素6/血液 白细胞介素18/血液 颈动脉/超声检查 

分 类 号：R743.31[医药卫生—神经病学与精神病学]