中枢神经系统感染患儿脑脊液中一氧化氮含量变化及其意义  

Detection of nitric oxide level in cerebrospinal fluid and its clinical significance in children with infection of central nervous system

作　　者：陈艳[1] 胡仁俊[1] 宋文秀[1] 江超[1] 

机构地区：[1]遵义医学院附一院儿科,563003

出　　处：《临床儿科杂志》2000年第2期95-97,共3页Journal of Clinical Pediatrics

摘　　要：为了探讨不同病因所致中枢神经系统感染后脑脊液中一氧化氮含量变化及其与感染病因、脑损害程度间的相关关系,对不同脑损害程度的病毒性脑炎、流行性脑脊髓膜炎患儿脑脊液中NO_2^-含量进行测定,并分析NO_2^-含量变化与感染原因、脑损害程度间的关系。结果表明:两组患儿脑脊液中NO_2^-含量明显上升(P<0.01),脑损害程度重的患儿NO_2^-含量高于脑损害程度轻的患儿(P<0.05)。结论:病毒性脑炎及流行性脑脊髓膜炎患儿脑脊液中NO_2^-含量均高于正常,其升高幅度 与脑损害程度相关,推测测量脑脊液中NO_2^-含量可能会有助于判断中枢神经系统感染性病变的脑损害程度。To explore the change of nitric oxide (NO2- )levels in cerebrospinal fluid in 28 children with epidemic cere-brospinal meningitis (ECM group) and 26 children with virus cerebritis (VC group),respectively. The relationship between NO2- level and infectious causes, the degree of brain injury were also analyzed. The results showed that the levels of NO2- increased significantly either in the ECM group or the VC group. No significantly difference of the NO2- level was observed in two groups. The NO2- level in children with serious brain injury were higher than that in children with no serious brain injury. It is suggested that the detection of NO2- level in cerebrospinal fluid will be helpful to evaluate the degree of brain injury in children with infections of central nervous system.

关 键 词：儿童 中枢神经系统感染 一氧化氮 脑脊液 

分 类 号：R748[医药卫生—神经病学与精神病学]