谷胱甘肽转硫酶M_1和T_1多态性与大肠癌易患性关系研究  

THE RELATIONSHIP BETWEEN POLYMORPHISM OF GSTM_1 AND GSTT_1 GENE AND GENETIC SUSCEPTIBILITY TO COLORECTAL CANCER

作　　者：周建农[1] 许发培[1] 李忠佑[1] 王建东[1] 李金田[1] 高长明[1] 王亚平[1] 

机构地区：[1]江苏省肿瘤防治研究所,南京210009

出　　处：《江苏临床医学杂志》2000年第2期90-91,94,共3页Journal of Jiangsu Clinical Medicine

基　　金：江苏省卫生厅重点资助!(H9805)

摘　　要：目的：了解江苏部分地区人群中谷胱甘肽转硫酶ＧＳＴＭ_１和ＧＳＴＴ_１基因多态性与大肠癌易患性的关系。方法：应用多重ＰＣＲ法．对照研究５５例大肠癌患者和６２例健康人的ＧＳＴＭ_１和ＧＳＴＴ_１基因频率。结果：在健康对照和大肠癌病例中，ＧＳＴＭ_１基因缺失频率分别为５３．２％和６１．８％，ＧＳＴＴ_１基因缺失频率分别为５０．０％和５６．４％，病例组基因缺失频率高于健康对照组，但无显著性差异（Ｐ＞０．０５）。结论：ＧＳＴＭ_１和ＧＳＴＴ_１基因缺失与大肠癌易患性和发病年龄无明显相关性。Objective: Investigating the relationship between polymorphism of GSTM1 and GSTT1 gene and genetic susceptibility to colorectal cancer (CRC). Methods: Genomic DNA of 55 cases with CRC and 62 healthy controls have been used to analysis the genotypes and genetic polymorphism of the GSTM1 and GSTT1 genes by multi-PCR. Results: In healthy control group and CRC patient group, the percentages of GSTM1 null type were 53.2% and 61. 8% respectively, whereas those of GSTT1 were 50.0% and 56.4%. Compared with the healthy control group, the percentage of null types in the patient group was higher, but no significant difference was found. Conclusions: The polymorphism of the GSTM1 and GSTT1 genes may be not related with genetic susceptibility to CRC and to the age of onset at CRC.

关 键 词：大肠肿瘤 遗传易感性 谷胱甘肽转硫酶 

分 类 号：R735.340.2[医药卫生—肿瘤]