含卡培他滨方案治疗复发转移性乳腺癌的临床观察  

The effect of Capecitabine containing regimens on 70 cases of recurrent metastatic breast cancer

作　　者：肖华伍[1] 欧阳取长[1] 

机构地区：[1]湖南省肿瘤医院乳腺内科,长沙410013

出　　处：《中国肿瘤临床与康复》2012年第3期221-223,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察含卡培他滨方案对蒽环类和(或)紫杉类药物治疗后复发转移性乳腺癌的疗效和不良反应。方法 70例蒽环类和(或)紫杉类药物治疗后复发转移性乳腺癌患者分为两组,卡培他滨联合长春瑞滨(NX组,36例),卡培他滨800～1000mg/m2,分早晚两次服用,第1～14天,长春瑞滨25mg/m2,第1天和第8天,静脉滴注,3周为1个周期。卡培他滨联合吉西他滨(GX组,34例),卡培他滨800～1000mg/m2,分早晚两次服用,第1～14天,吉西他滨1g/m2,静脉滴注,第1天和第8天,3周为1个周期。每两个周期评价疗效,均至少治疗2个周期以上。结果 NX组患者中,完全缓1例(2.8%),部分缓解20例(55.6%),疾病稳定11例(30.6%),疾病进展4例(11.1%),有效率为58.3%,中位疾病进展时间13.5个月;完全缓解1例(2.9%),部分缓解19例(55.9%),疾病稳定12例(35.3%),疾病进展2例(5.9%),有效率为58.8%,中位疾病进展时间13.8月。常见的不良反应主要为骨髓抑制、胃肠道反应、手足综合征等。结论含卡培他滨方案治疗蒽环类和(或)紫杉类药物治疗后复发转移乳腺癌疗效确切,毒性可耐受,是治疗复发转移性乳腺癌的较好方案。Objective To observe the efficacy and security of capecitabine - contained regimens for patients with recurrent metastatic breast cancer after docetaxel and anthracycline treatment. Methods A total of 70 cases were recruited. Thirty - six patients received NX regimen （ NVB 25mg/m^2 on day 1 and day 8, capecitabine 800 - 1000 mg . m^-2. d^-1, dl - 14,repeated every 3 weeks. ,in the GX（34） group capecitabine 800 - 1000 mg . m^-2 . d^-1, dl - 14, gemcitabine lg/m2 ,on day 1 and day 8 . The treatment was repeated every 3 weeks,two cycles at least. The efficacy was evaluated every 2 cycles. Results In the NX group, CR was achieved in 1 cases（2. 8% ）, PR in20 case.s（55. 6% ）, SD in 11 cases（30. 6% ）, and PD in 4 cases（ 11.1% ）. The response rate in the NX group was 58. 3% , in the GX group CR was achieved in 1 case（2. 9% ）, PR in 19cases（55.9% ）, SD in 12 cases（35.3% ）, and PD 2 case（5.9% ） . The re- sponse rate in the GX group was 58.8%. The median time to progress was 13.5 months, in the NX group and 13.8 months in the GX group. The common toxicities included myelosuppression, gastrointestinal reac- tions and, hand - foot syndrome. Conclusions Capecitabine - contained regimens can achieve good results for recurrent metastatic breast cancer after docetaxel and anthracycline treatment, with tolerable side effects.

关 键 词：晚期转移性乳腺癌 卡培他滨 长春瑞滨 吉西他滨 

分 类 号：R737.9[医药卫生—肿瘤]