肺癌组织雌/孕激素受体、DNA含量的测定及其临床意义  

Detection of estrogen/progesterone receptor and DNA content in lung cancer and its clinical significance

作　　者：彭爱梅 朱晓莉[2] 李基业[2] 

机构地区：[1]上海铁道大学附属铁路医院呼吸内科,上海200072 [2]南京铁道医学院附属医院呼吸内科,江苏南京210009

出　　处：《铁道医学》2000年第2期81-83,共3页Railway Medical Journal

基　　金：铁道部卫生司基金资助项目! (J97TW77)

摘　　要：目的　探讨雌 /孕激素受体 (ER/PR)在肺癌的临床病理意义 ,研究肺癌的激素受体表达、DNA含量及其与生物学特性的关系。方法　应用免疫组织化学SP法检测肺癌组织ER/PR ,流式细胞仪检测DNA含量。结果　 4 0例肺癌ER检测阳性 2 3例 (57.5% ) ,PR检测阳性 16例 (4 0 .0 % ) ,异倍体者 31例 (77.5% ) ;受体阳性率与组织学分级呈负相关 ,并与病理类型有关 ;ER阳性者DI值较低 ,以二倍体多见。结论　肺癌组织中存在雌 /孕激素受体 ,能用以反映其生物学行为 。Objective To study the expression of hormone receptor and the relationship between estrogen/progesterone receptor (ER/PR)and DNA content and the biological features in lung cancer.Methods ER/PR was detected in lung cancer fresh resected or biopsy specimens with immunohistochemistry method, DNA content was measured with flow cytometry. Results The positive rates of ER and PR were 57.5%(23/40)and 40.0%(16/40),the rate of heteroploid was 77.5%(31/40);The positive rate of receptor had negative correlation with histopathologic grade and was related to the pathologic classification of lung neoplasm cells.In ER positive group,the DI was lower and the incidence of diploid was higher.Conclusions There are ER and PR in tissues of lung cancer, and the levels of them can reflect biologic behaviors. Simultaneous detection of ER/PR and DNA content can provide base for clinical endocrine treatment and evaluation of prognosis in lung cancer.

关 键 词：雌激素 受体 孕激素 肺肿瘤 DNA ER/PR 

分 类 号：R734.202[医药卫生—肿瘤]