2-取代-3-N-酰基-5-氟-4-嘧啶酮的合成及其抗肿瘤活性(英文)  

The Synthesis of 2-Substituted-3-acyl-5-fluoro-4-pyrimidones and Their Antitumor Activities

作　　者：孙昌俊[1] 李洪祥[1] 李吉海[1] 王义贵[1] 戚聿新[1] 张纪明[1] 刘书银[2] 

机构地区：[1]山东大学化学系,济南250100 [2]枣庄师范专科学校化学系,枣庄277160

出　　处：《合成化学》2000年第3期248-251,共4页Chinese Journal of Synthetic Chemistry

摘　　要：在丙酮溶液中 ,于 Et3 N存在下使 2 -取代 - 5-氟 - 4 -嘧啶酮与酰氯反应 ,合成了 1 4个未见文献报道的 2 -取代 - 3- N-酰基 - 5-氟 - 4 -嘧啶酮类化合物 ,它们的结构经 IR,1H NMR,元素分析或 MS确定。其中有些化合物具有一定的抗肿瘤活性。Fourteen new 2-substituted-3-acyl-5-fluoro-4-pyrimidone compounds were prepared by the reaction of 2-substituted-5-fluoro-3H-4-pyrimidones with acyl chlorides in acetone in the presence of Et_3N. Their structures were confirmed by IR, 1H NMR and elementary analysis or MS. The preliminary antitumor tests showed that some of them exhibited certain activities.

关 键 词：5-氟腺嘧啶 酰氯 合成 嘧啶酮 抗肿瘤活性 

分 类 号：O626.4[理学—有机化学] O621.29[理学—化学]